Lobophorin C and D, New Kijanimicin Derivatives from a Marine Sponge-Associated Actinomycetal Strain AZS17

doi:10.3390/md9030359

IOCAS-IR > 实验海洋生物学重点实验室

	Lobophorin C and D, New Kijanimicin Derivatives from a Marine Sponge-Associated Actinomycetal Strain AZS17
	Wei, Rong-Bian 1,2,3; Xi, Tao 3; Li, Jing4 ; Wang, Ping 2; Li, Fu-Chao 1; Lin, Yong-Cheng 4; Qin, Song 1
	2011-03-01
发表期刊	MARINE DRUGS
ISSN	1660-3397
卷号	9 期号:3 页码:359-368
文章类型	Article
摘要	Marine sponge Hymeniacidon sp. was collected from coastal waters of the East China Sea to isolate symbiotic microorganisms. The resulting sponge-associated actinomycete, Streptomyces carnosus strain AZS17, was cultivated in a 20 L volume of medium for production of bioactive secondary metabolites. Bioassay-guided isolation and purification by varied chromatographic methods yielded two new compounds of kijanimicin derivatives, AS7-2 and AS9-12. Their structures were elucidated by spectroscopy and comparison with literatures. Results showed these two compounds were structurally similar to the previously reported compounds lobophorin A and B, yet differed in specific bond forms, stereochemistry and optical activities. The two novel compounds were named lobophorin C and D. In vitro cytotoxicity investigation by MTT assay indicated their selective activities. Lobophorin C displayed potent cytotoxic activity against the human liver cancer cell line 7402, while lobophorin D showed significant inhibitory effect on human breast cancer cells MDA-MB 435.; Marine sponge Hymeniacidon sp. was collected from coastal waters of the East China Sea to isolate symbiotic microorganisms. The resulting sponge-associated actinomycete, Streptomyces carnosus strain AZS17, was cultivated in a 20 L volume of medium for production of bioactive secondary metabolites. Bioassay-guided isolation and purification by varied chromatographic methods yielded two new compounds of kijanimicin derivatives, AS7-2 and AS9-12. Their structures were elucidated by spectroscopy and comparison with literatures. Results showed these two compounds were structurally similar to the previously reported compounds lobophorin A and B, yet differed in specific bond forms, stereochemistry and optical activities. The two novel compounds were named lobophorin C and D. In vitro cytotoxicity investigation by MTT assay indicated their selective activities. Lobophorin C displayed potent cytotoxic activity against the human liver cancer cell line 7402, while lobophorin D showed significant inhibitory effect on human breast cancer cells MDA-MB 435.
关键词	Marine Sponge Actinomycete Lobophorin c And d Cytotoxic Activity
学科领域	Pharmacology & Pharmacy
DOI	10.3390/md9030359
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000288892900006
引用统计	被引频次：56[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/11891
专题	实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Open Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Zhejiang Ocean Univ, Coll Marine Sci, Zhoushan 316004, Peoples R China 3.China Pharmaceut Univ, Marine Drugs Res Ctr, Nanjing 210018, Peoples R China 4.Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China
第一作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Wei, Rong-Bian,Xi, Tao,Li, Jing,et al. Lobophorin C and D, New Kijanimicin Derivatives from a Marine Sponge-Associated Actinomycetal Strain AZS17[J]. MARINE DRUGS,2011,9(3):359-368.
APA	Wei, Rong-Bian.,Xi, Tao.,Li, Jing.,Wang, Ping.,Li, Fu-Chao.,...&Qin, Song.(2011).Lobophorin C and D, New Kijanimicin Derivatives from a Marine Sponge-Associated Actinomycetal Strain AZS17.MARINE DRUGS,9(3),359-368.
MLA	Wei, Rong-Bian,et al."Lobophorin C and D, New Kijanimicin Derivatives from a Marine Sponge-Associated Actinomycetal Strain AZS17".MARINE DRUGS 9.3(2011):359-368.

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