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| Tissue-specific response of metallothionein and superoxide dismutase in the clam Mactra veneriformis under sublethal mercury exposure | |
Fang, Yan1,2; Yang, Hongsheng1 ; Liu, Baozhong1; Yang, HS (reprint author), Chinese Acad Sci, Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China.
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| 2012-08-01 | |
| 发表期刊 | ECOTOXICOLOGY
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| ISSN | 0963-9292 |
| 卷号 | 21期号:6页码:1593-1602 |
| 文章类型 | Article |
| 摘要 | To identify the relationship between mercury (Hg) and stress responses in the clam Mactra veneriformis, metallothionein (MT) and superoxide dismutase (SOD) mRNA expression in the digestive gland, gill, and mantle as well as MT protein content and SOD activity in the digestive gland were examined under sublethal Hg exposure at doses of 10, 20, and 40 mu g/L for 21 days. The ranking of the tissues in decreasing order of their basal MvMT and MvSOD mRNA expression is as follows: digestive gland > mantle > gill > adductor muscle > foot and digestive gland > mantle > gill > foot > adductor muscle, respectively. Hg exposure significantly elevated MvMT and MvSOD mRNA transcripts in the digestive gland, gill, and mantle in a tissue-specific way. In the digestive gland, a dose-dependent increase of MvMT and MvSOD mRNA expression, stimulation of MT protein, and alteration of SOD activity were observed under Hg stress. MT protein responded later than MT mRNA to Hg exposure and no clear relationship was found between them, indicating the occurrence of posttranscriptional events. All of the results suggest that MT and SOD cooperate in resisting Hg toxicity and maintaining cellular metabolic homeostasis in M. veneriformis. MT and SOD mRNA expressions have great potential as biomarkers of Hg pollution in the aquatic environment for the studied species. |
| 关键词 | Metallothionein Superoxide Dismutase Mercury Mrna Expression Mactra Veneriformis |
| 学科领域 | Ecology ; Environmental Sciences ; Toxicology |
| DOI | 10.1007/s10646-012-0938-8 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000306592100003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/12452 |
| 专题 | 海洋生态与环境科学重点实验室 实验海洋生物学重点实验室 |
| 通讯作者 | Yang, HS (reprint author), Chinese Acad Sci, Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China. |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China 2.Grad Univ, Chinese Acad Sci, Beijing 100049, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Fang, Yan,Yang, Hongsheng,Liu, Baozhong,et al. Tissue-specific response of metallothionein and superoxide dismutase in the clam Mactra veneriformis under sublethal mercury exposure[J]. ECOTOXICOLOGY,2012,21(6):1593-1602. |
| APA | Fang, Yan,Yang, Hongsheng,Liu, Baozhong,&Yang, HS .(2012).Tissue-specific response of metallothionein and superoxide dismutase in the clam Mactra veneriformis under sublethal mercury exposure.ECOTOXICOLOGY,21(6),1593-1602. |
| MLA | Fang, Yan,et al."Tissue-specific response of metallothionein and superoxide dismutase in the clam Mactra veneriformis under sublethal mercury exposure".ECOTOXICOLOGY 21.6(2012):1593-1602. |
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