| Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118 | |
Shang Zhuo2,3; Li Xiaoming3; Meng Li1 ; Li Chunshun3; Gao Shushan2,3; Huang Caiguo1; Wang Bingui3; Huang, CG (reprint author), Mil Med Coll 2, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China.
| |
| 2012-03-01 | |
| 发表期刊 | CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
 |
| ISSN | 0254-4059 |
| 卷号 | 30期号:2页码:305-314 |
| 文章类型 | Article |
| 摘要 | Bioassay-guided fractionation of the crude extract from Penicillium commune SD-118, a fungus obtained from a deep-sea sediment sample, resulted in the isolation of a known antibacterial compound, xanthocillin X (1), and 14 other known compounds comprising three steroids (2-4), two ceramides (5 and 6), six aromatic compounds (7-12), and three alkaloids (13-15). Xanthocillin X (1) was isolated for the first time from a marine fungus. In the bioassay, xanthocillin X (1) displayed remarkable antimicrobial activity against Staphylococcus aureus and Escherichia coli, and significant cytotoxicity against MCF-7, HepG2, H460, Hela, Du145, and MDA-MB-231 cell lines. Meleagrin (15) exhibited cytotoxicity against HepG2, Hela, Du145, and MDA-MB-231 cell lines. This is the first report of the cytotoxicity of xanthocillin X (1). |
| 关键词 | Bioguided Isolation Deep-sea Sediment-derived Fungus Penicillium Commune Xanthocillin x Antibacterial Activity Cytotoxicity |
| 学科领域 | Limnology ; Oceanography |
| DOI | 10.1007/s00343-012-1075-1 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000301001900015 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/12528 |
| 专题 | 海洋生物分类与系统演化实验室 实验海洋生物学重点实验室 |
| 通讯作者 | Huang, CG (reprint author), Mil Med Coll 2, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China. |
| 作者单位 | 1.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China |
| 第一作者单位 | 实验海洋生物学重点实验室 |
| 推荐引用方式 GB/T 7714 | Shang Zhuo,Li Xiaoming,Meng Li,et al. Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2012,30(2):305-314. |
| APA | Shang Zhuo.,Li Xiaoming.,Meng Li.,Li Chunshun.,Gao Shushan.,...&Huang, CG .(2012).Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118.CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,30(2),305-314. |
| MLA | Shang Zhuo,et al."Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 30.2(2012):305-314. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Chemical profile of （526KB） | 限制开放 | 使用许可 | 浏览 | |||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论