Development of a 3-hydroxypropionate resistant Escherichia coli strain

doi:10.1080/21655979.2015.1122143

IOCAS-IR > 实验海洋生物学重点实验室

	Development of a 3-hydroxypropionate resistant Escherichia coli strain
	Liu, Min 1,2; Han, Xueping 1,2; Xian, Mo 1; Ding, Yamei 3; Liu, Huizhou 1; Zhao, Guang 1
	2016
发表期刊	BIOENGINEERED
卷号	7 期号:1 页码:21-27
文章类型	Article
摘要	3-hydroxypropionate (3HP) is an important platform chemical, and its biosynthesis is severely restricted by the toxicity of 3HP on cell growth and survival. To improve Escherichia coli resistance to 3HP and reduce the total production cost in industrial applications, we have identified variations in protein expression level exposed to sub-lethal concentration of this chemical using 2-dimensional gel electrophoresis. Under 3HP stress, the amount of 46 proteins was increased while the amount of 23 proteins was reduced. According to the proteomic results, overexpression of some identified proteins significantly increased the E. coli survival rate under 3HP stress. This study shed light on clues for developing E. coli strains with higher resistance to 3HP toxicity and lower production cost for industrial applications.
关键词	Bacterial Stress Response Comparative Proteomics Escherichia Coli 3-hydroxypropionate 3-hydroxypropionate Resistance
DOI	10.1080/21655979.2015.1122143
收录类别	SCI
语种	英语
WOS记录号	WOS:000373159100009
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
版本	出版稿
条目标识符	http://ir.qdio.ac.cn/handle/337002/126243
专题	实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Key Lab Biobased Mat, Qingdao, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Liu, Min,Han, Xueping,Xian, Mo,et al. Development of a 3-hydroxypropionate resistant Escherichia coli strain[J]. BIOENGINEERED,2016,7(1):21-27.
APA	Liu, Min,Han, Xueping,Xian, Mo,Ding, Yamei,Liu, Huizhou,&Zhao, Guang.(2016).Development of a 3-hydroxypropionate resistant Escherichia coli strain.BIOENGINEERED,7(1),21-27.
MLA	Liu, Min,et al."Development of a 3-hydroxypropionate resistant Escherichia coli strain".BIOENGINEERED 7.1(2016):21-27.

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文件名称/大小	文献类型	版本类型	开放类型	使用许可
Development of a 3-h（569KB）	期刊论文	出版稿	限制开放	CC BY-NC-SA	浏览