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| Low molecular weight fucoidan ameliorates the inflammation and glomerular filtration function of diabetic nephropathy | |
Xu, Yingjie1,2,3 ; Zhang, Quanbin1,4,5; Luo, Dali6; Wang, Jing1,4; Duan, Delin1,4,5
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| 2017-02-01 | |
| 发表期刊 | JOURNAL OF APPLIED PHYCOLOGY
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| 卷号 | 29期号:1页码:531-542 |
| 文章类型 | Article |
| 摘要 | Diabetic nephropathy (DN) is a type of serious microangiopathy that is caused by diabetes mellitus (DM). It is the most common cause of chronic renal failure and end-stage renal disease, and it severely affects patients' quality of life. This work aims to study the effect and mechanism of low molecular weight fucoidan (LMWF) on streptozotocin (STZ)-induced DN. The experimental results showed that LMWF prevented weight loss in DN rats, significantly reduced the levels of biochemical indexes in blood and urine samples, and also lowered hyaluronic acid (HA) levels and advanced glycosylation end product-specific receptor (AGER) levels in DN rats. LMWF maintained the structural integrity of glomerular basement membrane (GBM) and glomerulus, improved the glomerular filtration function, protected glycosaminoglycan from abnormal degrading, prevented advanced glycosylation end product (AGE) from being generated and accumulating, and also alleviated inflammatory response in DN rats. LMWF could obviously ameliorate and slow the development and progression of DN in rats. |
| 关键词 | Fucoidan Diabetic Nephropathy Hspg Glycosaminoglycan Inflammatory Cytokines |
| DOI | 10.1007/s10811-016-0942-0 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000396344800047 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 版本 | 出版稿 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/136791 |
| 专题 | 实验海洋生物学重点实验室 海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Univ, Inst Cerebrovasc Dis, Affiliated Hosp, Qingdao 266003, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China 5.State Key Lab Seaweed Bioact Subst, Qingdao, Peoples R China 6.Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Dept Pharmacol, Beijing 100069, Peoples R China |
| 第一作者单位 | 实验海洋生物学重点实验室 |
| 推荐引用方式 GB/T 7714 | Xu, Yingjie,Zhang, Quanbin,Luo, Dali,et al. Low molecular weight fucoidan ameliorates the inflammation and glomerular filtration function of diabetic nephropathy[J]. JOURNAL OF APPLIED PHYCOLOGY,2017,29(1):531-542. |
| APA | Xu, Yingjie,Zhang, Quanbin,Luo, Dali,Wang, Jing,&Duan, Delin.(2017).Low molecular weight fucoidan ameliorates the inflammation and glomerular filtration function of diabetic nephropathy.JOURNAL OF APPLIED PHYCOLOGY,29(1),531-542. |
| MLA | Xu, Yingjie,et al."Low molecular weight fucoidan ameliorates the inflammation and glomerular filtration function of diabetic nephropathy".JOURNAL OF APPLIED PHYCOLOGY 29.1(2017):531-542. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Low molecular weight（1443KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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