| Comparison in docetaxel-loaded nanoparticles based on three different carboxymethyl chitosans | |
Zhang, Enhui1,2,3 ; Xing, Ronge1,3; Liu, Song1,3; Li, Kecheng1,3; Qin, Yukun1,3; Yu, Huahua1,3; Li, Pengcheng1,3
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| 2017-08-01 | |
| 发表期刊 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| 卷号 | 101页码:1012-1018 |
| 文章类型 | Article |
| 摘要 | In this study, three different carboxymethyl chitosans (CMCs), namely O-carboxymethyl chitosan (OC), N-carboxymethyl chitosan (NC) and N,O-carboxymethyl chitosan (NOC), were prepared as nano-carriers for an anti-tumor drug, docetaxel (DCT). Three CMCs were fabricated into drug-loading nanoparticles under different preparing conditions respectively. A series of characterization parameters were determined including drug loading capacity (DC), entrapment efficiency (EE), particle size distribution, zeta potential, and morphology, which were used to find the optimized preparing condition for three kinds of nanoparticles (NPs). Furthermore, the in vitro drug release profiles of all the three kinds of nanoparticles showed a sustained release behavior and the release rate of OC-NPs was the fastest. Moreover, compared with NC-NPs and NOC-NPs, OC-NPs exhibited more cellular accumulation in the human gastric carcinoma cells (SGC 7901) as quantitatively determined by the flow cytometry and also much stronger cytotoxicity against these cells. Accordingly, our results showed that drug-loaded nanoparticles formed by different CMCs have dissimilar physiochemical characteristics which subsequently influence their" therapeutic effects. We suggest that OC-based nanoparticle is a more desirable anti-tumor drug delivery system than NC-NP and NOC-NP. (C) 2017 Elsevier B.V. All rights reserved. |
| 关键词 | Carboxymethyl Chitosan Nanoparticle Anti-tumor |
| DOI | 10.1016/j.ijbiomac.2017.03.195 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000404491300110 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 版本 | 出版稿 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/137032 |
| 专题 | 海洋生物技术研发中心 实验海洋生物学重点实验室 海洋环境工程技术研究发展中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, 7 Nanhai Rd, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, 7 Nanhai Rd, Qingdao 266071, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Enhui,Xing, Ronge,Liu, Song,et al. Comparison in docetaxel-loaded nanoparticles based on three different carboxymethyl chitosans[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2017,101:1012-1018. |
| APA | Zhang, Enhui.,Xing, Ronge.,Liu, Song.,Li, Kecheng.,Qin, Yukun.,...&Li, Pengcheng.(2017).Comparison in docetaxel-loaded nanoparticles based on three different carboxymethyl chitosans.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,101,1012-1018. |
| MLA | Zhang, Enhui,et al."Comparison in docetaxel-loaded nanoparticles based on three different carboxymethyl chitosans".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 101(2017):1012-1018. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Comparison in doceta（2407KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 | |
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