Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Chinikomycins A and B: Isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp isolate M045 | |
Li, FC; Maskey, RP; Qin, S; Sattler, I; Fiebig, HH; Maier, A; Zeeck, A; Laatsch, H; Laatsch, H, Univ Gottingen, Dept Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany | |
2005-03-01 | |
发表期刊 | JOURNAL OF NATURAL PRODUCTS |
ISSN | 0163-3864 |
卷号 | 68期号:3页码:349-353 |
文章类型 | Article |
摘要 | In our screening of marine Streptomycetes for bioactive principles, two novel antitumor antibiotics designated as chinikomycins A (2a) and B (2b) were isolated together with manumycin A (1), and their structures were elucidated by a detailed interpretation of their spectra. Chinikomycins A (2a) and B (2b) are chlorine-containing aromatized manumycin derivatives of the type 64-pABA-2 with an unusual para orientation of the side chains. They exhibited antitumor activity against different human cancer cell lines, but were inactive in antiviral, antimicrobial, and phytotoxicity tests.; In our screening of marine Streptomycetes for bioactive principles, two novel antitumor antibiotics designated as chinikomycins A (2a) and B (2b) were isolated together with manumycin A (1), and their structures were elucidated by a detailed interpretation of their spectra. Chinikomycins A (2a) and B (2b) are chlorine-containing aromatized manumycin derivatives of the type 64-pABA-2 with an unusual para orientation of the side chains. They exhibited antitumor activity against different human cancer cell lines, but were inactive in antiviral, antimicrobial, and phytotoxicity tests. |
关键词 | Manumycin |
学科领域 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
DOI | 10.1021/np030518r |
URL | 查看原文 |
收录类别 | SCI ; IC |
语种 | 英语 |
WOS记录号 | WOS:000227927700008 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qdio.ac.cn/handle/337002/1629 |
专题 | 实验海洋生物学重点实验室 |
通讯作者 | Laatsch, H, Univ Gottingen, Dept Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany |
作者单位 | 1.Univ Gottingen, Dept Organ & Biomol Chem, D-37077 Gottingen, Germany 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Oncotest GmbH, D-79108 Freiburg, Germany |
推荐引用方式 GB/T 7714 | Li, FC,Maskey, RP,Qin, S,et al. Chinikomycins A and B: Isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp isolate M045[J]. JOURNAL OF NATURAL PRODUCTS,2005,68(3):349-353. |
APA | Li, FC.,Maskey, RP.,Qin, S.,Sattler, I.,Fiebig, HH.,...&Laatsch, H, Univ Gottingen, Dept Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany.(2005).Chinikomycins A and B: Isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp isolate M045.JOURNAL OF NATURAL PRODUCTS,68(3),349-353. |
MLA | Li, FC,et al."Chinikomycins A and B: Isolation, structure elucidation, and biological activity of novel antibiotics from a marine Streptomyces sp isolate M045".JOURNAL OF NATURAL PRODUCTS 68.3(2005):349-353. |
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