Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
The ERK-MNK-eIF4F signaling pathway mediates TPDHT-induced A549 cell death in vitro and in vivo | |
Guo, Chuanlong1,2; Hou, Yuzhen1,2; Yu, Xuemin3; Zhang, Fan1,2; Wu, Xiaochen1,2; Wu, Xianggen1,2; Wang, Lijun4 | |
2020-03-01 | |
发表期刊 | FOOD AND CHEMICAL TOXICOLOGY |
ISSN | 0278-6915 |
卷号 | 137页码:10 |
通讯作者 | Wu, Xianggen(wuxianggen@126.com) ; Wang, Lijun(wanglijun@qdio.ac.cn) |
摘要 | The eIF4E/eIF4G complex plays a central role in gene expression regulation during the initial stage of translation. This study aimed to determine if the novel small molecule compound, TPDHT, could disrupt the interaction of eIF4E/eIF4G, and if it could exhibit excellent antitumor activity in vivo without causing apparent toxicity effect. This study investigated the antitumor mechanism of TPDHT in vitro and in vivo. TPDHT showed significant anti-proliferative activity on human lung cancer A549 cells, and it induced G0/G1 cycle arrest. Moreover, TPDHT also induced A549 cell apoptosis through the mitochondria-mediated apoptotic pathway. Our results indicate that TPDHT could disrupt the interaction of eIF4E/eIF4G, and the activity of eIF4F plays an important role in TPDHT-induced cell proliferation inhibition and apoptosis. Further research showed that TPDHT could inhibit the Ras/ERK/MNK pathway, and activation of the ERK pathway reversed TPDHT-induced cell proliferation inhibition and apoptosis. Taken together, our study findings indicated that TPDHT exerts an antitumor effect through an intrinsic apoptotic pathway controlled by the ERK/MNK/eIF4F pathway. |
关键词 | Apoptosis eIF4F ERK MNK A549 cells |
DOI | 10.1016/j.fct.2020.111158 |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[81773586] ; Talent Fund of Shandong Collaborative Innovation Center of Eco-Chemical Engineering[XTCXQN19] |
WOS研究方向 | Food Science & Technology ; Toxicology |
WOS类目 | Food Science & Technology ; Toxicology |
WOS记录号 | WOS:000517659300016 |
出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qdio.ac.cn/handle/337002/165632 |
专题 | 实验海洋生物学重点实验室 |
通讯作者 | Wu, Xianggen; Wang, Lijun |
作者单位 | 1.Qingdao Univ Sci & Technol, Coll Chem Engn, Dept Pharm, Qingdao 266042, Peoples R China 2.Qingdao Univ Sci & Technol, Key Lab Pharmaceut Res Metab Dis, Qingdao, Peoples R China 3.Shandong Univ, Qilu Hosp, NHC Key Lab Otorhinolaryngol, Dept Otorhinolaryngol, Shandong 266035, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China |
通讯作者单位 | 实验海洋生物学重点实验室 |
推荐引用方式 GB/T 7714 | Guo, Chuanlong,Hou, Yuzhen,Yu, Xuemin,et al. The ERK-MNK-eIF4F signaling pathway mediates TPDHT-induced A549 cell death in vitro and in vivo[J]. FOOD AND CHEMICAL TOXICOLOGY,2020,137:10. |
APA | Guo, Chuanlong.,Hou, Yuzhen.,Yu, Xuemin.,Zhang, Fan.,Wu, Xiaochen.,...&Wang, Lijun.(2020).The ERK-MNK-eIF4F signaling pathway mediates TPDHT-induced A549 cell death in vitro and in vivo.FOOD AND CHEMICAL TOXICOLOGY,137,10. |
MLA | Guo, Chuanlong,et al."The ERK-MNK-eIF4F signaling pathway mediates TPDHT-induced A549 cell death in vitro and in vivo".FOOD AND CHEMICAL TOXICOLOGY 137(2020):10. |
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文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
1-s2.0-S027869152030(2640KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 |
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