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Triazoles and Other N-Containing Metabolites from the Marine-Derived Endophytic Fungus Penicillium chrysogenum EN-118
An, Chun-Yan1,2; Li, Xiao-Ming1; Li, Chun-Shun1; Gao, Shu-Shan1,2; Shang, Zhuo1,2; Wang, Bin-Gui1; Wang, BG
2013-04-01
发表期刊HELVETICA CHIMICA ACTA
ISSN0018-019X
卷号96期号:4页码:682-687
文章类型Article
摘要Two new triazoles, chrysotriazoles A and B (1 and 2, resp.), along with two known quinazolinones, 3 and 4, two known 2-(4-hydroxyphenyl)acetamides, 5 and 6, and two known N-(4-hydroxystyryl)formamides, 7 and 8, were isolated and identified from the culture extract of Penicillium chrysogenum EN-118, an endophytic fungus obtained from the marine brown alga Sargassum pallidium. The structures of the isolated compounds were elucidated by NMR-spectroscopic analysis, and that of compound 1 was confirmed by X-ray crystallographic analysis of its p-bromobenzoate derivative. Compounds 4, 5, and 7 showed moderate cytotoxicities against Du145, A-549, and HeLa cell lines.; Two new triazoles, chrysotriazoles A and B (1 and 2, resp.), along with two known quinazolinones, 3 and 4, two known 2-(4-hydroxyphenyl)acetamides, 5 and 6, and two known N-(4-hydroxystyryl)formamides, 7 and 8, were isolated and identified from the culture extract of Penicillium chrysogenum EN-118, an endophytic fungus obtained from the marine brown alga Sargassum pallidium. The structures of the isolated compounds were elucidated by NMR-spectroscopic analysis, and that of compound 1 was confirmed by X-ray crystallographic analysis of its p-bromobenzoate derivative. Compounds 4, 5, and 7 showed moderate cytotoxicities against Du145, A-549, and HeLa cell lines.
关键词Sargassum Pallidium Penicillium Chrysogenum Chrysotriazoles a And b Cytotoxic Activity
学科领域Chemistry
DOI10.1002/hlca.201200433
URL查看原文
收录类别SCI ; IC
语种英语
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
WOS记录号WOS:000317492200012
WOS关键词ASPERGILLUS-OCHRACEUS ; CHAETOMIUM-GLOBOSUM ; NATURAL-PRODUCTS ; ESSRAMYCIN ; ALKALOIDS ; STEROIDS ; QEN-24S ; NIGER
WOS标题词Science & Technology ; Physical Sciences
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被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/16669
专题实验海洋生物学重点实验室
通讯作者Wang, BG
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
第一作者单位实验海洋生物学重点实验室
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An, Chun-Yan,Li, Xiao-Ming,Li, Chun-Shun,et al. Triazoles and Other N-Containing Metabolites from the Marine-Derived Endophytic Fungus Penicillium chrysogenum EN-118[J]. HELVETICA CHIMICA ACTA,2013,96(4):682-687.
APA An, Chun-Yan.,Li, Xiao-Ming.,Li, Chun-Shun.,Gao, Shu-Shan.,Shang, Zhuo.,...&Wang, BG.(2013).Triazoles and Other N-Containing Metabolites from the Marine-Derived Endophytic Fungus Penicillium chrysogenum EN-118.HELVETICA CHIMICA ACTA,96(4),682-687.
MLA An, Chun-Yan,et al."Triazoles and Other N-Containing Metabolites from the Marine-Derived Endophytic Fungus Penicillium chrysogenum EN-118".HELVETICA CHIMICA ACTA 96.4(2013):682-687.
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