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Subchronic toxicity study of ulvan from Ulva pertusa (Chlorophyta) in Wistar rats
Qi, Huimin1,2; Liu, Xiaolei3; Wang, Kai1; Liu, Dongmei1; Huang, Liye4; Liu, Shunmei1; Zhang, Quanbin2; Zhang, QB
2013-12-01
发表期刊FOOD AND CHEMICAL TOXICOLOGY
ISSN0278-6915
卷号62页码:573-578
文章类型Article
摘要Ulvan extracted from Ulva pertusa (Chlorophyta) is a group of sulfated heteropolysaccharide, for simplicity, the sulfated polysaccharide is referred to as ulvan in this paper. To our knowledge, there is no detailed report investigating the toxicity of ulvan. In this study, the subchronic (6 months) toxicity of varying levels of ulvan extracted from U. pertusa was investigated in Wistar rats after oral administration. ALT, ALB, ALP, WBC, PLT, and liver relative organ weigh of female rats showed significantly difference at 3000 mg/kg body weight per day, compared with control group. On the other hand, TG, T-CHO concentrations of female rats (6 months) were significantly decreased at 600, 1200 and 3000 mg/kg body weight per day. This result proved that ulvan had antihyperlipidemic activity. Beside, ulvan showed anticoagulant activity in this study. Overall, our findings indicated that ulvan had affected specific hematology, serum biochemistry parameters and liver, and had great differences between males and females rats. (C) 2013 Elsevier Ltd. All rights reserved.; Ulvan extracted from Ulva pertusa (Chlorophyta) is a group of sulfated heteropolysaccharide, for simplicity, the sulfated polysaccharide is referred to as ulvan in this paper. To our knowledge, there is no detailed report investigating the toxicity of ulvan. In this study, the subchronic (6 months) toxicity of varying levels of ulvan extracted from U. pertusa was investigated in Wistar rats after oral administration. ALT, ALB, ALP, WBC, PLT, and liver relative organ weigh of female rats showed significantly difference at 3000 mg/kg body weight per day, compared with control group. On the other hand, TG, T-CHO concentrations of female rats (6 months) were significantly decreased at 600, 1200 and 3000 mg/kg body weight per day. This result proved that ulvan had antihyperlipidemic activity. Beside, ulvan showed anticoagulant activity in this study. Overall, our findings indicated that ulvan had affected specific hematology, serum biochemistry parameters and liver, and had great differences between males and females rats. (C) 2013 Elsevier Ltd. All rights reserved.
关键词Ulvan Ulva Pertusa Subchronic Toxicity Rats
学科领域Food Science & Technology ; Toxicology
DOI10.1016/j.fct.2013.09.022
URL查看原文
收录类别SCI
语种英语
WOS研究方向Food Science & Technology ; Toxicology
WOS类目Food Science & Technology ; Toxicology
WOS记录号WOS:000329960400075
WOS关键词WEIGHT SULFATED POLYSACCHARIDES ; ANTIOXIDANT ACTIVITY ; FIBERS ; ALGAE
WOS标题词Science & Technology ; Life Sciences & Biomedicine
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/16722
专题海洋生物技术研发中心
通讯作者Zhang, QB
作者单位1.Weifang Med Univ, Weifang 261053, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
3.Weifang Univ, Weifang 261061, Peoples R China
4.Shandong Inst Sci & Tech Informat, Jinan 250101, Peoples R China
第一作者单位中国科学院海洋研究所
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Qi, Huimin,Liu, Xiaolei,Wang, Kai,et al. Subchronic toxicity study of ulvan from Ulva pertusa (Chlorophyta) in Wistar rats[J]. FOOD AND CHEMICAL TOXICOLOGY,2013,62:573-578.
APA Qi, Huimin.,Liu, Xiaolei.,Wang, Kai.,Liu, Dongmei.,Huang, Liye.,...&Zhang, QB.(2013).Subchronic toxicity study of ulvan from Ulva pertusa (Chlorophyta) in Wistar rats.FOOD AND CHEMICAL TOXICOLOGY,62,573-578.
MLA Qi, Huimin,et al."Subchronic toxicity study of ulvan from Ulva pertusa (Chlorophyta) in Wistar rats".FOOD AND CHEMICAL TOXICOLOGY 62(2013):573-578.
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