A new steroid with 7 beta,8 beta-epoxidation from the deep sea-derived fungus Aspergillus penicillioides SD-311

doi:10.1080/10286020.2020.1791096

IOCAS-IR > 实验海洋生物学重点实验室

	A new steroid with 7 beta,8 beta-epoxidation from the deep sea-derived fungus Aspergillus penicillioides SD-311
	Chi, Lu-Ping1,2 ; Yang, Sui-Qun 1,3,4; Li, Xiao-Ming 1,3,4; Li, Xiao-Dong1 ; Wang, Bin-Gui1,3,4 ; Li, Xin1,3,4
	2020-07-10
发表期刊	JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
ISSN	1028-6020
页码	8
通讯作者	Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Li, Xin(lixin@qdio.ac.cn)
摘要	7 beta,8 beta-epoxy-(22E,24R)-24-methylcholesta-4,22-diene-3,6-dione (1), a new steroid, along with five known analogues (2-6), was isolated from the deep sea-derived fungus,Aspergillus penicillioidesSD-311. Strikingly,1possessed a rare 7,8-epoxidation moiety. Meanwhile, this is the first time to report natural products from this fungus species. The structures were established by extensive spectroscopic analysis. The absolute configuration was determined by X-ray diffraction experiments. Compound1showed antibacterial activity againstVibrio anguillarumwith MIC value of 32.0 mu g/mL, while2displayed inhibitions againstEdwardsiella tardaandMicrococcus luteuswith MIC values both of 16 mu g/mL. [GRAPHICS] .
关键词	Aspergillus penicillioides deep sea-derived fungus 7 beta,8 beta-epoxy steroid marine natural products
DOI	10.1080/10286020.2020.1791096
收录类别	SCI
语种	英语
资助项目	Strategic Priority Research Program of Chinese Academy of Sciences[XDA22050401] ; Aoshan Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology[2016ASKJ14] ; National Natural Science Foundation of China[31700043]
WOS研究方向	Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
WOS类目	Plant Sciences ; Chemistry, Applied ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号	WOS:000547747800001
出版者	TAYLOR & FRANCIS LTD
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/167823
专题	实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui; Li, Xin
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing 100864, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
第一作者单位	实验海洋生物学重点实验室
通讯作者单位	实验海洋生物学重点实验室; 中国科学院海洋大科学研究中心
推荐引用方式 GB/T 7714	Chi, Lu-Ping,Yang, Sui-Qun,Li, Xiao-Ming,et al. A new steroid with 7 beta,8 beta-epoxidation from the deep sea-derived fungus Aspergillus penicillioides SD-311[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2020:8.
APA	Chi, Lu-Ping,Yang, Sui-Qun,Li, Xiao-Ming,Li, Xiao-Dong,Wang, Bin-Gui,&Li, Xin.(2020).A new steroid with 7 beta,8 beta-epoxidation from the deep sea-derived fungus Aspergillus penicillioides SD-311.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,8.
MLA	Chi, Lu-Ping,et al."A new steroid with 7 beta,8 beta-epoxidation from the deep sea-derived fungus Aspergillus penicillioides SD-311".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2020):8.

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