Fabrication of guanidinylated chitosan nanoparticles loaded with bioactive factors for facilitating wound healing

doi:10.1080/00914037.2020.1817017

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	Fabrication of guanidinylated chitosan nanoparticles loaded with bioactive factors for facilitating wound healing
	Li, Ling 1; Xing, Ronge2 ; Li, Jinguo 3; Li, Pengcheng2
	2020-09-12
发表期刊	INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
ISSN	0091-4037
页码	7
通讯作者	Li, Jinguo(likang8688@163.com) ; Li, Pengcheng(pcli@qdio.ac.cn)
摘要	Developing wound dressings that improve healing and minimize scarring is of great importance. Chitosan, widely used in biomedical materials, and the chemicals, food and cosmetics fields, shows poor wound healing abilities. In addition, bioactive factors such as epidermal growth factor (EGF) and 1,25-dihydroxyvitamin D-3(VD3), which are significant for stimulating skin fibroblasts and keratinocyte proliferation, have limited applicability because they are unstable in wound dressing fabrication and storage. Here we prepared guanidinylated chitosan nanoparticles loaded with five different bioactive factors (CGNP), including EGF, ascorbic acid (VC), hydrocortisone, insulin and VD3, and evaluated their wound healing ability. The results show that the size of CGNPs was about 200 nm, which is suitable for cellular uptake. CGNPs were used to treat skin wounds induced on Wistar rats. With the treatment, complete healing was observed after 24 days, while untreated wounds and those treated with chitosan were irregular. Moreover, wounds treated with CGNP1 showed color and smoothness similar to normal skin after recovery after 28 days. CGNPs may be possible wound dressings for stable delivery of bioactive factors, enhancement of wound healing and avoidance scarring.
关键词	Bioactive factors chitosan guanidine nanoparticle scar wound healing
DOI	10.1080/00914037.2020.1817017
收录类别	SCI
语种	英语
资助项目	NSFC-Shandong Union[U1406402-5] ; independent innovation Project of Shandong Province[2013CXB80203] ; CAS STS Program[KFJ-SW-STS-143] ; Public Science and Technology Research Funds Projects of Ocean[201405038-2] ; Public Science and Technology Research Funds Projects of Ocean[201305016-2]
WOS研究方向	Materials Science ; Polymer Science
WOS类目	Materials Science, Biomaterials ; Polymer Science
WOS记录号	WOS:000571078400001
出版者	TAYLOR & FRANCIS AS
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/168918
专题	中国科学院海洋研究所
通讯作者	Li, Jinguo; Li, Pengcheng
作者单位	1.Hunan Univ Sci & Engn, Yongzhou, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China 3.Shandong Wei Kang Biomed Technol Co Ltd, Linyi, Shandong, Peoples R China
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Li, Ling,Xing, Ronge,Li, Jinguo,et al. Fabrication of guanidinylated chitosan nanoparticles loaded with bioactive factors for facilitating wound healing[J]. INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS,2020:7.
APA	Li, Ling,Xing, Ronge,Li, Jinguo,&Li, Pengcheng.(2020).Fabrication of guanidinylated chitosan nanoparticles loaded with bioactive factors for facilitating wound healing.INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS,7.
MLA	Li, Ling,et al."Fabrication of guanidinylated chitosan nanoparticles loaded with bioactive factors for facilitating wound healing".INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS (2020):7.

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