Clustering genomic organization of sea cucumber miRNAs impacts their evolution and expression

doi:10.1016/j.ygeno.2021.08.003

IOCAS-IR > 实验海洋生物学重点实验室

	Clustering genomic organization of sea cucumber miRNAs impacts their evolution and expression
	Liu, Chengzhang 1; Yuan, Jianbo 1,2; Zhang, Xiaojun 1,2; Jin, Songjun 1,2; Li, Fuhua 1,2,3; Xiang, Jianhai1,2,3
	2021-11-01
发表期刊	GENOMICS
ISSN	0888-7543
卷号	113 期号:6 页码:3544-3555
通讯作者	Zhang, Xiaojun(xjzhang@qdio.ac.cn) ; Xiang, Jianhai(jhxiang@qdio.ac.cn)
摘要	Echinoderms are marine deuterostomes with fascinating adaptation features such as aestivation and organ regeneration. However, post-transcriptional gene regulation by microRNAs (miRNAs) underlying these features are largely unexplored. Here, using homology-based and de novo approaches supported by expression data, we provided a comprehensive annotation of miRNA genes in the sea cucumber Apostichopus japonicus. By linkage and phylogenic analyses, we characterized miRNA genomic organization, evolutionary history and expression regulation. The results showed that sea cucumbers evolved a large number of new miRNAs, which tended to form polycistronic clusters via tandem duplication that had been especially active in the echinoderms. Most new miRNAs were weakly expressed, but miRNA clustering increased the expression level of clustered new miRNAs. The most abundantly expressed new miRNAs were organized in a single tandem cluster (cluster n2), which was activated during aestivation and intestine regeneration. Overall, our analyses suggest that clustering of miRNAs is important for their evolutionary origin, expression control, and functional cooperation.
关键词	microRNA miRNA cluster Sea cucumber Aestivation Regeneration
DOI	10.1016/j.ygeno.2021.08.003
收录类别	SCI
语种	英语
资助项目	Ocean Science Data Center, Institute of Oceanology, CAS ; National Natural Science Foundation of China[31772885] ; National Key R&D Program of China[2018YFD0900103] ; Senior User Project of RV KEXUE[KEXUE2018G19]
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS记录号	WOS:000703997800002
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/176495
专题	实验海洋生物学重点实验室
通讯作者	Zhang, Xiaojun; Xiang, Jianhai
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所; 中国科学院海洋大科学研究中心
推荐引用方式 GB/T 7714	Liu, Chengzhang,Yuan, Jianbo,Zhang, Xiaojun,et al. Clustering genomic organization of sea cucumber miRNAs impacts their evolution and expression[J]. GENOMICS,2021,113(6):3544-3555.
APA	Liu, Chengzhang,Yuan, Jianbo,Zhang, Xiaojun,Jin, Songjun,Li, Fuhua,&Xiang, Jianhai.(2021).Clustering genomic organization of sea cucumber miRNAs impacts their evolution and expression.GENOMICS,113(6),3544-3555.
MLA	Liu, Chengzhang,et al."Clustering genomic organization of sea cucumber miRNAs impacts their evolution and expression".GENOMICS 113.6(2021):3544-3555.

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