Comparative Genomics of Exiguobacterium Reveals What Makes a Cosmopolitan Bacterium

doi:10.1128/mSystems.00383-21

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	Comparative Genomics of Exiguobacterium Reveals What Makes a Cosmopolitan Bacterium
	Zhang, Dechao 1,2,3; Zhu, Zhaolu 4,5; Li, Yangjie 4,5; Li, Xudong 4,5; Guan, Ziyu 4; Zheng, Jinshui 4,5
	2021-08-01
发表期刊	MSYSTEMS
ISSN	2379-5077
卷号	6 期号:4 页码:18
通讯作者	Zhu, Zhaolu(zhaoluzhu@gmail.com) ; Zheng, Jinshui(jszheng@mail.hzau.edu.cn)
摘要	Although the strategies used by bacteria to adapt to specific environmental conditions are widely reported, fewer studies have addressed how microbes with a cosmopolitan distribution can survive in diverse ecosystems. Exiguobacterium is a versatile genus whose members are commonly found in various habitats. To better understand the mechanisms underlying the universality of Exiguobacterium, we collected 105 strains from diverse environments and performed large-scale metabolic and adaptive ability tests. We found that most Exiguobacterium members have the capacity to survive under wide ranges of temperature, salinity, and pH. According to phylogenetic and average nucleotide identity analyses, we identified 27 putative species and classified two genetic groups: groups I and II. Comparative genomic analysis revealed that the Exiguobacterium members utilize a variety of complex polysaccharides and proteins to support survival in diverse environments and also employ a number of chaperonins and transporters for this purpose. We observed that the group I species can be found in more diverse terrestrial environments and have a larger genome size than the group II species. Our analyses revealed that the expansion of transporter families drove genomic expansion in group I strains, and we identified 25 transporter families, many of which are involved in the transport of important substrates and resistance to environmental stresses and are enriched in group I strains. This study provides important insights into both the overall general genetic basis for the cosmopolitan distribution of a bacterial genus and the evolutionary and adaptive strategies of Exiguobacterium. IMPORTANCE The wide distribution characteristics of Exiguobacterium make it a valuable model for studying the adaptive strategies of bacteria that can survive in multiple habitats. In this study, we reveal that members of the Exiguobacterium genus have a cosmopolitan distribution and share an extensive adaptability that enables them to survive in various environments. The capacities shared by Exiguobacterium members, such as their diverse means of polysaccharide utilization and environmental-stress resistance, provide an important basis for their cosmopolitan distribution. Furthermore, the selective expansion of transporter families has been a main driving force for genomic evolution in Exiguobacterium. Our findings improve our understanding of the adaptive and evolutionary mechanisms of cosmopolitan bacteria and the vital genomic traits that can facilitate niche adaptation.
关键词	Exiguobacterium cosmopolitan distribution genomics adaptation strategies polysaccharide utilization transporters
DOI	10.1128/mSystems.00383-21
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[31670002] ; National Natural Science Foundation of China[31970003] ; National Natural Science Foundation of China[31770003] ; Science & Technology Basic Resources Investigation Program of China[2017FY100804]
WOS研究方向	Microbiology
WOS类目	Microbiology
WOS记录号	WOS:000709924400016
出版者	AMER SOC MICROBIOLOGY
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/177132
专题	中国科学院海洋研究所
通讯作者	Zhu, Zhaolu; Zheng, Jinshui
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Peoples R China 4.Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan, Peoples R China 5.Huazhong Agr Univ, Coll Informat, Hubei Key Lab Agr Bioinformat, Wuhan, Peoples R China
第一作者单位	中国科学院海洋研究所; 中国科学院海洋大科学研究中心
推荐引用方式 GB/T 7714	Zhang, Dechao,Zhu, Zhaolu,Li, Yangjie,et al. Comparative Genomics of Exiguobacterium Reveals What Makes a Cosmopolitan Bacterium[J]. MSYSTEMS,2021,6(4):18.
APA	Zhang, Dechao,Zhu, Zhaolu,Li, Yangjie,Li, Xudong,Guan, Ziyu,&Zheng, Jinshui.(2021).Comparative Genomics of Exiguobacterium Reveals What Makes a Cosmopolitan Bacterium.MSYSTEMS,6(4),18.
MLA	Zhang, Dechao,et al."Comparative Genomics of Exiguobacterium Reveals What Makes a Cosmopolitan Bacterium".MSYSTEMS 6.4(2021):18.

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