Noncoding Variation and Transcriptional Plasticity Promote Thermal Adaptation in Oysters by Altering Energy Metabolism

doi:10.1093/molbev/msab241

IOCAS-IR > 实验海洋生物学重点实验室

	Noncoding Variation and Transcriptional Plasticity Promote Thermal Adaptation in Oysters by Altering Energy Metabolism
	Li, Ao 1,2,3; Li, Li 1,3,4,5; Zhang, Ziyan 1,3,5; Li, Shiming 6,7; Wang, Wei 1,3,4; Guo, Ximing 8; Zhang, Guofan 1,2,3
	2021-11-01
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
卷号	38 期号:11 页码:5144-5155
通讯作者	Li, Li(lili@qdio.ac.cn) ; Zhang, Guofan(gzhang@qdio.ac.cn)
摘要	Genetic variation and phenotypic plasticity are both important to adaptive evolution. However, how they act together on particular traits remains poorly understood. Here, we integrated phenotypic, genomic, and transcriptomic data from two allopatric but closely related congeneric oyster species, Crassostrea angulata from southern/warm environments and Crassostrea gigas from northern/cold environments, to investigate the roles of genetic divergence and plasticity in thermal adaptation. Reciprocal transplantation experiments showed that both species had higher fitness in their native habitats than in nonnative environments, indicating strong adaptive divergence. The southern species evolved higher transcriptional plasticity, and the plasticity was adaptive, suggesting that increased plasticity is important for thermal adaptation to warm climates. Genome-wide comparisons between the two species revealed that genes under selection tended to respond to environmental changes and showed higher sequence divergence in noncoding regions. All genes under selection and related to energy metabolism exhibited habitat-specific expression with genes involved in ATP production and lipid catabolism highly expressed in warm/southern habitats, and genes involved in ATP consumption and lipid synthesis were highly expressed in cold/northern habitats. The gene for acyl-CoA desaturase, a key enzyme for lipid synthesis, showed strong selective sweep in the upstream noncoding region and lower transcription in the southern species. These results were further supported by the lower free fatty acid (FFA) but higher ATP content in southern species and habitat, pointing to significance of ATP/FFA trade-off. Our findings provide evidence that noncoding variation and transcriptional plasticity play important roles in shaping energy metabolism for thermal adaptation in oysters.
关键词	thermal adaptation plasticity noncoding variation lipid synthesis ATP consumption oyster
DOI	10.1093/molbev/msab241
收录类别	SCI
语种	英语
资助项目	National Key R&D Program of China[2018YFD0900304] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA23050402] ; Distinguished Young Scientists Research Fund of Key Laboratory of Experimental Marine Biology, Chinese Academy of Sciences[KLEMB-DYS04] ; China Postdoctoral Science Foundation[2019TQ0324] ; Key Deployment Project of Centre for Ocean Mega-Research of Science, Chinese Academy of Sciences[COMS2019Q06] ; National Natural Science Foundation of China[31572620] ; Technology and Modern AgroIndustry Technology Research System[CARS-49]
WOS研究方向	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
WOS类目	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
WOS记录号	WOS:000715560700037
出版者	OXFORD UNIV PRESS
引用统计	被引频次：25[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/177201
专题	实验海洋生物学重点实验室海洋生态与环境科学重点实验室
通讯作者	Li, Li; Zhang, Guofan
作者单位	1.Chinese Acad Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Ctr Ocean Megasci, Inst Oceanol, Qingdao, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Key Lab Ecol Mariculture, Qingdao, Peoples R China 4.Pilot Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China 6.BGI Shenzhen, BGI Genom, Shenzhen, Peoples R China 7.BGI Argo Seed Serv Wuhan Co Ltd, Wuhan, Peoples R China 8.Rutgers State Univ, Dept Marine & Coastal Sci, Haskin Shellfish Res Lab, Port Norris, NJ USA
第一作者单位	中国科学院海洋大科学研究中心; 中国科学院海洋研究所
通讯作者单位	中国科学院海洋大科学研究中心; 中国科学院海洋研究所
推荐引用方式 GB/T 7714	Li, Ao,Li, Li,Zhang, Ziyan,et al. Noncoding Variation and Transcriptional Plasticity Promote Thermal Adaptation in Oysters by Altering Energy Metabolism[J]. MOLECULAR BIOLOGY AND EVOLUTION,2021,38(11):5144-5155.
APA	Li, Ao.,Li, Li.,Zhang, Ziyan.,Li, Shiming.,Wang, Wei.,...&Zhang, Guofan.(2021).Noncoding Variation and Transcriptional Plasticity Promote Thermal Adaptation in Oysters by Altering Energy Metabolism.MOLECULAR BIOLOGY AND EVOLUTION,38(11),5144-5155.
MLA	Li, Ao,et al."Noncoding Variation and Transcriptional Plasticity Promote Thermal Adaptation in Oysters by Altering Energy Metabolism".MOLECULAR BIOLOGY AND EVOLUTION 38.11(2021):5144-5155.

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