Toxicological effects of cadmium on the immune response and biomineralization of larval flounder Paralichthys olivaceus under seawater acidification

doi:10.1016/j.chemosphere.2021.132919

	Toxicological effects of cadmium on the immune response and biomineralization of larval flounder Paralichthys olivaceus under seawater acidification
	Cui, Wenting 1,3; Liu, Jinhu 1,2; Cao, Liang 1,2; Dou, Shuozeng 1,2,3
	2022-03-01
发表期刊	CHEMOSPHERE
ISSN	0045-6535
卷号	291 页码:12
通讯作者	Cao, Liang(caoliang@qdio.ac.cn) ; Dou, Shuozeng(szdou@qdio.ac.cn)
摘要	Seawater acidification can cause threats to both calcifying and uncalcifying marine organisms, affecting their acid-base regulatory functions, immune system and biomineralization. Marine pollutants, such as cadmium (Cd) that is globally distributed in coastal ecosystems, do not affect organisms alone but commonly as combined stressors. To investigate the toxicological effects of Cd on the immune and biomineralization of marine fishes under seawater acidification, flounder Paralichthys olivaceus was exposed to seawater acidification (control (pH 8.10), 7.70 and 7.30) and Cd exposure (control (0.36 mu g L-1), 0.01 and 0.15 mg L-1 Cd) for 49 days from embryonic stage until they became settled. Immune and biomineralization-related biomarkers of flounder at the end of exposure were investigated. Results showed that single seawater acidification and Cd exposure or combined exposure significantly affected the immune system-related enzyme activities. Specifically, lysozyme (LZM) activity was significantly inhibited by single seawater acidification and Cd exposure, indicating innate immunosuppression under two stressors. Contents of IgM, HSP70 and MT were induced by seawater acidification or Cd exposure, indicating a detoxification mechanism that responded to the stressors. The expressions of immune related genes were upregulated (hsp70 and mt) or downregulated (lzm) under Cd exposure. Of the biomineralization-related enzymes, activities of carbonic anhydrase (CA), Na+/K+-ATPase and Ca2+-ATPase increased under seawater acidification and Cd exposure, a potential mechanism in response to changes of acid -base balance induced by the stressors. Generally, immune and biomineralization of the flounder responded more sensitively to Cd exposure than seawater acidification. Seawater acidification aggravated the toxicological effects of Cd exposure on the two physiological functions, while high Cd exposure augmented their responses to seawater acidification.
关键词	Ocean acidification Cd Immunotoxicity Acid-base regulation Biomineralization Fish larvae
DOI	10.1016/j.chemosphere.2021.132919
收录类别	SCI
语种	英语
资助项目	Special Project on Blue Granary Science and Technology Innovation under the National Key RD Pro-gram[2019YFD0902102] ; National Natural Science Foundation of China (NSFC) under the program Science Fund for Creative Research Groups[41121064] ; National Natural Science Foundation of China (NSFC) under the program Science Fund for Creative Research Groups[40821004]
WOS研究方向	Environmental Sciences & Ecology
WOS类目	Environmental Sciences
WOS记录号	WOS:000757983200007
出版者	PERGAMON-ELSEVIER SCIENCE LTD
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/178072
专题	海洋生态与环境科学重点实验室
通讯作者	Cao, Liang; Dou, Shuozeng
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
第一作者单位	海洋生态与环境科学重点实验室
通讯作者单位	海洋生态与环境科学重点实验室
推荐引用方式 GB/T 7714	Cui, Wenting,Liu, Jinhu,Cao, Liang,et al. Toxicological effects of cadmium on the immune response and biomineralization of larval flounder Paralichthys olivaceus under seawater acidification[J]. CHEMOSPHERE,2022,291:12.
APA	Cui, Wenting,Liu, Jinhu,Cao, Liang,&Dou, Shuozeng.(2022).Toxicological effects of cadmium on the immune response and biomineralization of larval flounder Paralichthys olivaceus under seawater acidification.CHEMOSPHERE,291,12.
MLA	Cui, Wenting,et al."Toxicological effects of cadmium on the immune response and biomineralization of larval flounder Paralichthys olivaceus under seawater acidification".CHEMOSPHERE 291(2022):12.

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