Cyclopiumolides A and B, unusual 13-membered macrolides from the deep sea-sourced fungus Penicillium cyclopium SD-413 with antiproliferative activities

doi:10.1016/j.bioorg.2022.106104

IOCAS-IR > 实验海洋生物学重点实验室

	Cyclopiumolides A and B, unusual 13-membered macrolides from the deep sea-sourced fungus Penicillium cyclopium SD-413 with antiproliferative activities
	Li, Yan-He1,2,3,4 ; Yang, Sui-Qun 1,2,3; Li, Xiao-Ming 1,2,3; Li, Xin1,2,3 ; Wang, Bin-Gui1,2,3,4,5,6 ; Li, Hong-Lei1,2,3,6
	2022-11-01
发表期刊	BIOORGANIC CHEMISTRY
ISSN	0045-2068
卷号	128 页码:7
通讯作者	Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Li, Hong-Lei(lihonglei@qdio.ac.cn)
摘要	Cyclopiumolides A (1) and B (2), first representatives of two novel biosynthetic related 13-membered macrolides featuring an uncommon verrucosidinol unit condensed with a spiculisporic acidic moiety, were identified from the fungus Penicillium cyclopium SD-413, which was obtained from the deep-sea sediments collected in the East China Sea. The structures of cyclopiumolides A (1) and B (2) were identified on the basis of extensive NMR spectroscopic and mass spectrometric data analysis. Their relative and absolute configurations were determined by quantum mechanical calculations of ECD spectra comparing with that of experimental curves and by DP4 + NMR data calculations. Compounds 1 and 2 exhibited significant cytotoxic potencies against the tumor cell lines SF126, FaDu, and TE-1 with IC50 values ranging from 5.86 to 17.05 mu M. The inhibition modes and binding sites of 1 and 2 were inspected using molecular docking simulations.
关键词	Macrolides Penicillium cyclopium Deep-sea sediment Cytotoxicity
DOI	10.1016/j.bioorg.2022.106104
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[U2006203] ; National Natural Science Foundation of China[42076090] ; Shandong Provincial Natural Science Foundation[ZR2021ZD28] ; National Major Science and Technology Infrastructure from the Chinese Academy of Sciences ; Senior User Project of RV KEXUE[KEXUE2020GZ02] ; RV KEXUE of the National Major Science and Technology Infrastructure ; Chinese Academy of Sciences
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Organic
WOS记录号	WOS:000859336700004
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/180727
专题	实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui; Li, Hong-Lei
作者单位	1.Chinese Acad Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Inst Oceanol, Chinese Acad Sci, Shandong Prov Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 4.Univ Chinese Acad Sci, Coll Marine Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China 6.Inst Oceanol, Chinese Acad Sci, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所; 中国科学院海洋大科学研究中心
推荐引用方式 GB/T 7714	Li, Yan-He,Yang, Sui-Qun,Li, Xiao-Ming,et al. Cyclopiumolides A and B, unusual 13-membered macrolides from the deep sea-sourced fungus Penicillium cyclopium SD-413 with antiproliferative activities[J]. BIOORGANIC CHEMISTRY,2022,128:7.
APA	Li, Yan-He,Yang, Sui-Qun,Li, Xiao-Ming,Li, Xin,Wang, Bin-Gui,&Li, Hong-Lei.(2022).Cyclopiumolides A and B, unusual 13-membered macrolides from the deep sea-sourced fungus Penicillium cyclopium SD-413 with antiproliferative activities.BIOORGANIC CHEMISTRY,128,7.
MLA	Li, Yan-He,et al."Cyclopiumolides A and B, unusual 13-membered macrolides from the deep sea-sourced fungus Penicillium cyclopium SD-413 with antiproliferative activities".BIOORGANIC CHEMISTRY 128(2022):7.

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