Mining new meroterpenoids from the marine red alga-derived endophytic Penicillium chermesinum EN-480 by comparative transcriptome analysis

doi:10.1016/j.bioorg.2022.106021

IOCAS-IR > 实验海洋生物学重点实验室

	Mining new meroterpenoids from the marine red alga-derived endophytic Penicillium chermesinum EN-480 by comparative transcriptome analysis
	Hu, Xue-Yi1,2,3 ; Li, Xiao-Ming 1,2; Liu, Hui1,2 ; Wang, Bin-Gui1,2,3,4 ; Meng, Ling-Hong1,2,4
	2022-11-01
发表期刊	BIOORGANIC CHEMISTRY
ISSN	0045-2068
卷号	128 页码:8
通讯作者	Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Meng, Ling-Hong(menglh@ms.qdio.ac.cn)
摘要	As the development of genetic and bioinformatic, the strategy of "bottom-up", combined with genome and transcriptome techniques, was considered as an efficient and practical method to break through the limitation of traditional discovery of natural products. Generally, comparative transcriptome analysis could be useful to guide the optimization of fungal cultivation conditions in which the transcriptional level of interesting compounds is higher. The transcriptome analysis of the algal endophytic fungus Penicillium chermesinum EN-480 indicated that fermentation of this fungus in modified rice solid medium could produce some metabolites different from those cultivated in other media. Four new meroterpenoids (compounds 1-4, namely, chermesins E-H) were characterized and their structures were determined by HRESIMS and NMR spectra. The absolute configurations were confirmed by NOESY experiments, X-ray diffraction analysis, and comparison of ECD cotton effects. Antimicrobial activities against human- and aqua-bacteria as well as against plant-pathogenic fungi were assayed. The plausible biosynthesis pathway of these compounds was discussed.
关键词	Penicillium chermesinum Comparative transcriptome analysis Meroterpenoids Antimicrobial activitie Plausible biosynthesis pathway
DOI	10.1016/j.bioorg.2022.106021
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[42176115] ; Laboratory of Marine Biology and Biotechnology of the Qingdao National Laboratory for Marine Science and Technology[YQ2018NO08]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Organic
WOS记录号	WOS:001000178600001
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS关键词	NATURAL-PRODUCTS ; FUNGUS ; BIOSYNTHESIS ; REVEALS ; PATHWAY ; GENE
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/183214
专题	实验海洋生物学重点实验室
通讯作者	Wang, Bin-Gui; Meng, Ling-Hong
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao Natl Lab Marine Sci & Technol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Nanhai Rd 7, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Coll Marine Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Hu, Xue-Yi,Li, Xiao-Ming,Liu, Hui,et al. Mining new meroterpenoids from the marine red alga-derived endophytic Penicillium chermesinum EN-480 by comparative transcriptome analysis[J]. BIOORGANIC CHEMISTRY,2022,128:8.
APA	Hu, Xue-Yi,Li, Xiao-Ming,Liu, Hui,Wang, Bin-Gui,&Meng, Ling-Hong.(2022).Mining new meroterpenoids from the marine red alga-derived endophytic Penicillium chermesinum EN-480 by comparative transcriptome analysis.BIOORGANIC CHEMISTRY,128,8.
MLA	Hu, Xue-Yi,et al."Mining new meroterpenoids from the marine red alga-derived endophytic Penicillium chermesinum EN-480 by comparative transcriptome analysis".BIOORGANIC CHEMISTRY 128(2022):8.