Genome-Wide Comparative Analysis of SRCR Gene Superfamily in Invertebrates Reveals Massive and Independent Gene Expansions in the Sponge and Sea Urchin

doi:10.3390/ijms25031515

IOCAS-IR > 实验海洋生物学重点实验室

	Genome-Wide Comparative Analysis of SRCR Gene Superfamily in Invertebrates Reveals Massive and Independent Gene Expansions in the Sponge and Sea Urchin
	Peng, Zhangjie 1,2,3,4,5; Zhang, Wei 1,2,3; Fu, Hailun 1,2,3; Li, Yuzhu 1,2,3; Zhang, Chunyu 1,2,3; Li, Jie2,3,4,5,6 ; Chan, Jiulin 2,3,5,6; Zhang, Linlin 2,3,4,5,6
	2024-02-01
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN	1661-6596
卷号	25 期号:3 页码:18
通讯作者	Zhang, Linlin(linlinzhang@qdio.ac.cn)
摘要	Without general adaptative immunity, invertebrates evolved a vast number of heterogeneous non-self recognition strategies. One of those well-known adaptations is the expansion of the immune receptor gene superfamily coding for scavenger receptor cysteine-rich domain containing proteins (SRCR) in a few invertebrates. Here, we investigated the evolutionary history of the SRCR gene superfamily (SRCR-SF) across 29 metazoan species with an emphasis on invertebrates. We analyzed their domain architectures, genome locations and phylogenetic distribution. Our analysis shows extensive genome-wide duplications of the SRCR-SFs in Amphimedon queenslandica and Strongylocentrotus purpuratus. Further molecular evolution study reveals various patterns of conserved cysteines in the sponge and sea urchin SRCR-SFs, indicating independent and convergent evolution of SRCR-SF expansion during invertebrate evolution. In the case of the sponge SRCR-SFs, a novel motif with seven conserved cysteines was identified. Exon-intron structure analysis suggests the rapid evolution of SRCR-SFs during gene duplications in both the sponge and the sea urchin. Our findings across nine representative metazoans also underscore a heightened expression of SRCR-SFs in immune-related tissues, notably the digestive glands. This observation indicates the potential role of SRCR-SFs in reinforcing distinct immune functions in these invertebrates. Collectively, our results reveal that gene duplication, motif structure variation, and exon-intron divergence might lead to the convergent evolution of SRCR-SF expansions in the genomes of the sponge and sea urchin. Our study also suggests that the utilization of SRCR-SF receptor duplication may be a general and basal strategy to increase immune diversity and tissue specificity for the invertebrates.
关键词	SRCR gene family innate immunity gene duplication independent evolution motif analysis
DOI	10.3390/ijms25031515
收录类别	SCI
语种	英语
资助项目	Open project of BGI-Shenzhen of China Shenzhen[518000] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB42000000] ; National Natural Science Foundation of China[42376092] ; National Natural Science Foundation of China[41976088]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:001160198600001
出版者	MDPI
WOS关键词	CYSTEINE-RICH DOMAIN ; MULTIPLE SEQUENCE ALIGNMENT ; MOLECULAR-PATTERNS PAMPS ; SCAVENGER RECEPTOR ; CRYSTAL-STRUCTURE ; IMMUNE-SYSTEM ; INNATE ; RECOGNITION ; PROTEIN ; EVOLUTION
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/184445
专题	实验海洋生物学重点实验室
通讯作者	Zhang, Linlin
作者单位	1.Qingdao Agr Univ, Coll Life Sci, Sch Marine Sci & Engn, Qingdao 266109, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Ctr Deep, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Ctr Deep Sea Res, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 4.Univ Chinese Acad Sci, Coll Marine Sci, Beijing 100049, Peoples R China 5.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China 6.Chinese Acad Sci, Key Lab Breeding Biotechnol & Sustainable Aquacult, Qingdao 266071, Peoples R China
第一作者单位	中国科学院海洋研究所; 深海极端环境与生命过程研究中心
通讯作者单位	中国科学院海洋研究所; 深海极端环境与生命过程研究中心
推荐引用方式 GB/T 7714	Peng, Zhangjie,Zhang, Wei,Fu, Hailun,et al. Genome-Wide Comparative Analysis of SRCR Gene Superfamily in Invertebrates Reveals Massive and Independent Gene Expansions in the Sponge and Sea Urchin[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2024,25(3):18.
APA	Peng, Zhangjie.,Zhang, Wei.,Fu, Hailun.,Li, Yuzhu.,Zhang, Chunyu.,...&Zhang, Linlin.(2024).Genome-Wide Comparative Analysis of SRCR Gene Superfamily in Invertebrates Reveals Massive and Independent Gene Expansions in the Sponge and Sea Urchin.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,25(3),18.
MLA	Peng, Zhangjie,et al."Genome-Wide Comparative Analysis of SRCR Gene Superfamily in Invertebrates Reveals Massive and Independent Gene Expansions in the Sponge and Sea Urchin".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 25.3(2024):18.