Identification of Growth-Related Gene <i>BAMBI</i> and Analysis of Gene Structure and Function in the Pacific White Shrimp <i>Litopenaeus vannamei</i>

doi:10.3390/ani14071074

IOCAS-IR > 实验海洋生物学重点实验室

	Identification of Growth-Related Gene BAMBI and Analysis of Gene Structure and Function in the Pacific White Shrimp Litopenaeus vannamei
	Niu, Ruigang 1,2; Zhang, Xiaojun 1,2,3; Yu, Yang1,2,3 ; Bao, Zhenning 1,2; Yang, Junqing 1,2; Yuan, Jianbo 1,2,3; Li, Fuhua 1,2,3
	2024-04-01
发表期刊	ANIMALS
ISSN	2076-2615
卷号	14 期号:7 页码:24
通讯作者	Zhang, Xiaojun(xjzhang@qdio.ac.cn)
摘要	As one of the most important aquaculture species in the world, the improvement of growth traits of the Pacific white shrimp (Litopenaeus vannamei), has always been a primary focus. In this study, we conducted SNP-specific locus analysis and identified a growth-related gene, BAMBI, in L. vannamei. We analyzed the structure and function of LvBAMBI using genomic, transcriptomic, metabolomic, and RNA interference (RNAi) assays. The LvBAMBI possessed highly conserved structural domains and widely expressed in various tissues. Knockdown of LvBAMBI significantly inhibited the gain of body length and weight of the shrimp, underscoring its role as a growth-promoting factor. Specifically, knockdown of LvBAMBI resulted in a significant downregulation of genes involved in lipid metabolism, protein synthesis, catabolism and transport, and immunity. Conversely, genes related to glucose metabolism exhibited significant upregulations. Analysis of differential metabolites (DMs) in metabolomics further revealed that LvBAMBI knockdown may primarily affect shrimp growth by regulating biological processes related to lipid and glucose metabolism. These results suggested that LvBAMBI plays a crucial role in regulating lipid metabolism, glucose metabolism, and protein transport in shrimp. This study provides valuable insights for future research and utilization of BAMBI genes in shrimp and crustaceans.
关键词	single nucleotide polymorphism RNA interference RNA-seq lipid metabolism glucose metabolism
DOI	10.3390/ani14071074
收录类别	SCI
语种	英语
资助项目	Natural Sciences Foundation of China
WOS研究方向	Agriculture ; Veterinary Sciences ; Zoology
WOS类目	Agriculture, Dairy & Animal Science ; Veterinary Sciences ; Zoology
WOS记录号	WOS:001201606600001
出版者	MDPI
WOS关键词	DIFFERENTIATION ; BODY
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/185159
专题	实验海洋生物学重点实验室
通讯作者	Zhang, Xiaojun
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Key Lab Breeding Biotechnol & Sustainable Aquacult, Wuhan 430072, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Niu, Ruigang,Zhang, Xiaojun,Yu, Yang,et al. Identification of Growth-Related Gene BAMBI and Analysis of Gene Structure and Function in the Pacific White Shrimp Litopenaeus vannamei[J]. ANIMALS,2024,14(7):24.
APA	Niu, Ruigang.,Zhang, Xiaojun.,Yu, Yang.,Bao, Zhenning.,Yang, Junqing.,...&Li, Fuhua.(2024).Identification of Growth-Related Gene BAMBI and Analysis of Gene Structure and Function in the Pacific White Shrimp Litopenaeus vannamei.ANIMALS,14(7),24.
MLA	Niu, Ruigang,et al."Identification of Growth-Related Gene BAMBI and Analysis of Gene Structure and Function in the Pacific White Shrimp Litopenaeus vannamei".ANIMALS 14.7(2024):24.