The potential mechanisms for isoliquiritigenin on the growth and immune regulation o<i>f Penaeus vannamei </i>revealed by transcriptomic and metabolomic

doi:10.1016/j.aquaculture.2024.740945

IOCAS-IR > 实验海洋生物学重点实验室

	The potential mechanisms for isoliquiritigenin on the growth and immune regulation of Penaeus vannamei revealed by transcriptomic and metabolomic
	Yang, Xuanyi1,2,3 ; Liu, Mei 4; Liang, Qinlang 5; Jiang, Keyong 1,2; Wang, Baojie 1,2; Wang, Lei 1,2,3
	2024-08-30
发表期刊	AQUACULTURE
ISSN	0044-8486
卷号	589 页码:15
通讯作者	Wang, Baojie(wangbaojie@qdio.ac.cn) ; Wang, Lei(leiwang@qdio.ac.cn)
摘要	The resistance of Penaeus vannamei to disease invasion is crucial for the development of the shrimp industry. It is unknown whether isoliquiritigenin (ISL) can serve as an efficient immunostimulant for P. vannamei. The growth, antioxidant, apoptosis, and immunity were used to assess the feasibility of ISL as an immunostimulant. Transcriptomics and metabolomics were used to investigate the mechanism of immune stimulation by ISL. It was found that ISL had no effect on the survival rate of P. vannamei. Dietary ISL can enhance growth and the expressions of antioxidant, anti-stress, and immune (excluding antimicrobial peptides) related genes. Transcriptome analysis revealed that numerous up-regulated DEGs (differentially expressed genes) were involved in immune regulation. The significantly enriched functions and pathways of DEGs were commonly involved in metabolism and immunity. The DMs (differential metabolites) and key metabolite nodes were mostly mapped to the regulation of growth, nutrient metabolism, and immune response. In conclusion, dietary ISL can improve the growth, antioxidant capacity, stress resistance, and immunity of P. vannamei. These improvements may be achieved by regulating signaling pathways (Toll-like receptor signaling pathway, glutathione metabolism, signal transduction-related pathways, HIF-1 signaling pathway, PPAR signaling pathway) and altering the abundance of metabolite with antibacterial, anti-inflammatory, and antioxidant capabilities.
关键词	Isoliquiritigenin Immunity Growth Penaeus vanname Transcriptomic and metabolomic
DOI	10.1016/j.aquaculture.2024.740945
收录类别	SCI
语种	英语
资助项目	Fund of the Key R & D Project of Shandong Province[2023TZXD047] ; Shandong Provincial Natural Science Foundation[ZR2023MC096] ; Shandong Provincial Natural Science Foundation[DC6129I202120002]
WOS研究方向	Fisheries ; Marine & Freshwater Biology
WOS类目	Fisheries ; Marine & Freshwater Biology
WOS记录号	WOS:001231821500001
出版者	ELSEVIER
WOS关键词	PACIFIC WHITE SHRIMP ; LITOPENAEUS-VANNAMEI ; SIGNALING PATHWAY ; ANTIOXIDANT ; FISH ; TOLL ; INHIBITION ; FLAVONOIDS ; RESPONSES ; INNATE
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/185868
专题	实验海洋生物学重点实验室
通讯作者	Wang, Baojie; Wang, Lei
作者单位	1.Chinese Acad Sci, Qingdao, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Marine Sci Res Inst Shandong Prov, Shandong Key Lab Dis Control Mariculture, Qingdao, Peoples R China 5.Tongwei Fishery Technol Co Ltd, Chengdu, Peoples R China
第一作者单位	中国科学院海洋研究所
通讯作者单位	中国科学院海洋研究所
推荐引用方式 GB/T 7714	Yang, Xuanyi,Liu, Mei,Liang, Qinlang,et al. The potential mechanisms for isoliquiritigenin on the growth and immune regulation of Penaeus vannamei revealed by transcriptomic and metabolomic[J]. AQUACULTURE,2024,589:15.
APA	Yang, Xuanyi,Liu, Mei,Liang, Qinlang,Jiang, Keyong,Wang, Baojie,&Wang, Lei.(2024).The potential mechanisms for isoliquiritigenin on the growth and immune regulation of Penaeus vannamei revealed by transcriptomic and metabolomic.AQUACULTURE,589,15.
MLA	Yang, Xuanyi,et al."The potential mechanisms for isoliquiritigenin on the growth and immune regulation of Penaeus vannamei revealed by transcriptomic and metabolomic".AQUACULTURE 589(2024):15.