Volatile Organic Compounds Produced by a Deep-Sea Bacterium Efficiently Inhibit the Growth of <i>Pseudomonas aeruginosa</i> PAO1

doi:10.3390/md22050233

IOCAS-IR > 实验海洋生物学重点实验室

	*Volatile Organic Compounds Produced by a Deep-Sea Bacterium Efficiently Inhibit the Growth of Pseudomonas aeruginosa* PAO1**
	Hu, Yuanyuan 1,2,3,4,5; Liu, Ge 2,3,4,5; Sun, Chaomin 2,3,4,5,6; Wu, Shimei 1
	2024-05-01
发表期刊	MARINE DRUGS
卷号	22 期号:5 页码:17
通讯作者	Sun, Chaomin(sunchaomin@qdio.ac.cn) ; Wu, Shimei(shimeiwu2016@126.com)
摘要	The deep-sea bacterium Spongiibacter nanhainus CSC3.9 has significant inhibitory effects on agricultural pathogenic fungi and human pathogenic bacteria, especially Pseudomonas aeruginosa, the notorious multidrug-resistant pathogen affecting human public health. We demonstrate that the corresponding antibacterial agents against P. aeruginosa PAO1 are volatile organic compounds (VOCs, namely VOC-3.9). Our findings show that VOC-3.9 leads to the abnormal cell division of P. aeruginosa PAO1 by disordering the expression of several essential division proteins associated with septal peptidoglycan synthesis. VOC-3.9 hinders the biofilm formation process and promotes the biofilm dispersion process of P. aeruginosa PAO1 by affecting its quorum sensing systems. VOC-3.9 also weakens the iron uptake capability of P. aeruginosa PAO1, leading to reduced enzymatic activity associated with key metabolic processes, such as reactive oxygen species (ROS) scavenging. Overall, our study paves the way to developing antimicrobial compounds against drug-resistant bacteria by using volatile organic compounds.
关键词	antibacteria volatile organic compounds Pseudomonas aeruginosa PAO1 cell division biofilm
DOI	10.3390/md22050233
收录类别	SCI
语种	英语
资助项目	Science and Technology Innovation Project of Laoshan Laboratory
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号	WOS:001233505900001
出版者	MDPI
WOS关键词	ANTIBACTERIAL
引用统计
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/185940
专题	实验海洋生物学重点实验室
通讯作者	Sun, Chaomin; Wu, Shimei
作者单位	1.Qingdao Univ, Coll Life Sci, 308 Ningxia Rd, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Ctr Deep Sea Res, Qingdao 266071, Peoples R China 4.Qingdao Marine Sci & Technol Ctr, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China 5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 6.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 101408, Peoples R China
第一作者单位	中国科学院海洋研究所; 深海极端环境与生命过程研究中心
通讯作者单位	中国科学院海洋研究所; 深海极端环境与生命过程研究中心
推荐引用方式 GB/T 7714	Hu, Yuanyuan,Liu, Ge,Sun, Chaomin,et al. Volatile Organic Compounds Produced by a Deep-Sea Bacterium Efficiently Inhibit the Growth of Pseudomonas aeruginosa PAO1[J]. MARINE DRUGS,2024,22(5):17.
APA	Hu, Yuanyuan,Liu, Ge,Sun, Chaomin,&Wu, Shimei.(2024).Volatile Organic Compounds Produced by a Deep-Sea Bacterium Efficiently Inhibit the Growth of Pseudomonas aeruginosa PAO1.MARINE DRUGS,22(5),17.
MLA	Hu, Yuanyuan,et al."Volatile Organic Compounds Produced by a Deep-Sea Bacterium Efficiently Inhibit the Growth of Pseudomonas aeruginosa PAO1".MARINE DRUGS 22.5(2024):17.