Sesquiterpenes from the red alga Laurencia tristicha

doi:10.1021/np050096g

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	Sesquiterpenes from the red alga Laurencia tristicha
	Sun, J ; Shi, DY ; Ma, M ; Li, SA ; Wang, SJ; Han, LJ ; Yang, YC ; Fan, X ; Shi, JG ; He, L ; Shi, JG, Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
	2005-06-01
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	68 期号:6 页码:915-919
文章类型	Article
摘要	Seven new sesquiterpenes (1-7), together with seven known sesquiterpenes, aplysin (8), aplysinol (9), gossonorol (10), 7,10-epoxy-ar-bisabol-11-ol (11), 10-epi-7,10-epoxy-ar-bisabol-11-ol (12), johnstonol (13), and laurebiphenyl (14), have been isolated from the red alga Laurencia tristicha. The structures of new compounds were established as laur-11-en-2,10-diol (1), laur-11-en-10-ol (2), laur-11-en-1,10-diol (3), 4-bromo-1,10-epoxylaur-11-ene (4), cyclolauren-2-ol (5), laurentristich-4-ol (6), and ar-bisabol-9-en-7,11-diol (7) by means of spectroscopic methods including IR, HRMS, and ID and 21) NMR techniques. Compound 6 possessed a novel rearranged skeleton. All compounds were tested against several human cancer cell lines including lung adenocarcinoma (A549), stomach cancer (BGC-823), hepatoma (Bel 7402), colon cancer (HCT-8), and HELA cell lines. Laurebiphenyl (14) showed moderate cytotoxicity against all tested cell lines, with IC50 values of 1.68, 1.22, 1.91, 1.77, and 1.61 mu g/mL, respectively. Other compounds were inactive (IC50 > 10 mu g/mL).; Seven new sesquiterpenes (1-7), together with seven known sesquiterpenes, aplysin (8), aplysinol (9), gossonorol (10), 7,10-epoxy-ar-bisabol-11-ol (11), 10-epi-7,10-epoxy-ar-bisabol-11-ol (12), johnstonol (13), and laurebiphenyl (14), have been isolated from the red alga Laurencia tristicha. The structures of new compounds were established as laur-11-en-2,10-diol (1), laur-11-en-10-ol (2), laur-11-en-1,10-diol (3), 4-bromo-1,10-epoxylaur-11-ene (4), cyclolauren-2-ol (5), laurentristich-4-ol (6), and ar-bisabol-9-en-7,11-diol (7) by means of spectroscopic methods including IR, HRMS, and ID and 21) NMR techniques. Compound 6 possessed a novel rearranged skeleton. All compounds were tested against several human cancer cell lines including lung adenocarcinoma (A549), stomach cancer (BGC-823), hepatoma (Bel 7402), colon cancer (HCT-8), and HELA cell lines. Laurebiphenyl (14) showed moderate cytotoxicity against all tested cell lines, with IC50 values of 1.68, 1.22, 1.91, 1.77, and 1.61 mu g/mL, respectively. Other compounds were inactive (IC50 > 10 mu g/mL).
关键词	Halogenated Sesquiterpenes Dictyopteris-divaricata Okamurai Yamada Curcumene Ether Metabolites Derivatives Aplysin Obtusa Rearrangement Bromophenols
学科领域	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI	10.1021/np050096g
URL	查看原文
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000230153900017
引用统计	被引频次：97[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/1882
专题	海洋生物技术研发中心
通讯作者	Shi, JG, Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 3.Peking Union Med Coll, Beijing 100050, Peoples R China 4.Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China
推荐引用方式 GB/T 7714	Sun, J,Shi, DY,Ma, M,et al. Sesquiterpenes from the red alga Laurencia tristicha[J]. JOURNAL OF NATURAL PRODUCTS,2005,68(6):915-919.
APA	Sun, J.,Shi, DY.,Ma, M.,Li, SA.,Wang, SJ.,...&Shi, JG, Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.(2005).Sesquiterpenes from the red alga Laurencia tristicha.JOURNAL OF NATURAL PRODUCTS,68(6),915-919.
MLA	Sun, J,et al."Sesquiterpenes from the red alga Laurencia tristicha".JOURNAL OF NATURAL PRODUCTS 68.6(2005):915-919.

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