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Functional analysis on immune deficiency (IMD) homolog gene in Chinese shrimp Fenneropenaeus chinensis
Feng, Ningning1,2; Wang, Dongdong1,2; Wen, Rong1,2; Li, Fuhua1; Li, FH (reprint author), Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China.
2014-03-01
发表期刊MOLECULAR BIOLOGY REPORTS
卷号41期号:3页码:1437-1444
文章类型Article
摘要IMD pathway is an important signaling pathway in regulating the innate immunity of invertebrate. IMD is regarded as a key adaptor to link the extracellular signals and intracellular signals. In the present study, a full-length cDNA encoding an IMD homolog (FcIMD) was isolated from Chinese shrimp Fenneropenaeus chinensis. It consists of 767 bp with a 483 bp open reading frame encoding 160 amino acids. A death domain was predicted which is crucial to the immune function of IMD. Tissue expression analysis showed that FcIMD mRNA had different expression level in different tissues. The transcriptional expression of FcIMD in shrimp was significantly induced at early stage (1 h) after stimulation by Vibrio or Micrococcus which suggested its important role in the immunity of shrimp to bacterium infection. The expressions of shrimp antimicrobial peptides (AMPs) were affected when FcIMD was silenced by dsRNA interference. Through analyzing the expression of FcRelish, FcDorsal and FcJNK in FcIMD silenced shrimp at 1 h post Vibrio injection, we deduced that IMD was involved in Relish regulated signaling pathway, not in Dorsal or JNK regulated signaling pathway.
关键词Fcimd Innate Immunity Imd Pathway Amps
学科领域Biochemistry & Molecular Biology
DOI10.1007/s11033-013-2988-2
收录类别SCI
语种英语
WOS记录号WOS:000332000400027
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/24116
专题实验海洋生物学重点实验室
通讯作者Li, FH (reprint author), Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China.
作者单位1.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
第一作者单位中国科学院海洋研究所
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Feng, Ningning,Wang, Dongdong,Wen, Rong,et al. Functional analysis on immune deficiency (IMD) homolog gene in Chinese shrimp Fenneropenaeus chinensis[J]. MOLECULAR BIOLOGY REPORTS,2014,41(3):1437-1444.
APA Feng, Ningning,Wang, Dongdong,Wen, Rong,Li, Fuhua,&Li, FH .(2014).Functional analysis on immune deficiency (IMD) homolog gene in Chinese shrimp Fenneropenaeus chinensis.MOLECULAR BIOLOGY REPORTS,41(3),1437-1444.
MLA Feng, Ningning,et al."Functional analysis on immune deficiency (IMD) homolog gene in Chinese shrimp Fenneropenaeus chinensis".MOLECULAR BIOLOGY REPORTS 41.3(2014):1437-1444.
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