Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Mutual modulation between norepinephrine and nitric oxide in haemocytes during the mollusc immune response | |
Jiang, Qiufen1,2; Zhou, Zhi1; Wang, Lingling1; Yang, Chuanyan1; Wang, Jingjing1,2 ; Wu, Tiantian1; Song, Linsheng1; Wang, LL (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.
| |
| 2014-11-07 | |
| 发表期刊 | SCIENTIFIC REPORTS
 |
| 卷号 | 4页码:6963 |
| 文章类型 | Article |
| 摘要 | Nitric oxide (NO) is one of the most important immune molecules in innate immunity of invertebrates, and it can be regulated by norepinephrine in ascidian haemocytes. In the present study, the mutual modulation and underlying mechanism between norepinephrine and NO were explored in haemocytes of the scallop Chlamys farreri. After lipopolysaccharide stimulation, NO production increased to a significant level at 24 h, and norepinephrine concentration rose to remarkable levels at 3 h and 12 similar to 48 h. A significant decrease of NO production was observed in the haemocytes concomitantly stimulated with lipopolysaccharide and alpha-adrenoceptor agonist, while a dramatic increase of NO production was observed in the haemocytes incubated with lipopolysaccharide and beta-adrenoceptor agonist. Meanwhile, the concentration of cyclic adenosine monophosphate (cAMP) decreased significantly in the haemocytes treated by lipopolysaccharide and alpha/beta-adrenoceptor agonist, while the content of Ca2+ was elevated in those triggered by lipopolysaccharide and beta-adrenoceptor agonist. When the haemocytes was incubated with NO donor, norepinephrine concentration was significantly enhanced during 1 similar to 24 h. Collectively, these results suggested that norepinephrine exerted varied effects on NO production at different immune stages via a novel alpha/beta-adrenoceptor-cAMP/Ca2+ regulatory pattern, and NO might have a feedback effect on the synthesis of norepinephrine in the scallop haemocytes. |
| 学科领域 | Science & Technology - Other Topics |
| DOI | 10.1038/srep06963 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000344385100015 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/24132 |
| 专题 | 实验海洋生物学重点实验室 |
| 通讯作者 | Wang, LL (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China. |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 第一作者单位 | 实验海洋生物学重点实验室 |
| 推荐引用方式 GB/T 7714 | Jiang, Qiufen,Zhou, Zhi,Wang, Lingling,et al. Mutual modulation between norepinephrine and nitric oxide in haemocytes during the mollusc immune response[J]. SCIENTIFIC REPORTS,2014,4:6963. |
| APA | Jiang, Qiufen.,Zhou, Zhi.,Wang, Lingling.,Yang, Chuanyan.,Wang, Jingjing.,...&Wang, LL .(2014).Mutual modulation between norepinephrine and nitric oxide in haemocytes during the mollusc immune response.SCIENTIFIC REPORTS,4,6963. |
| MLA | Jiang, Qiufen,et al."Mutual modulation between norepinephrine and nitric oxide in haemocytes during the mollusc immune response".SCIENTIFIC REPORTS 4(2014):6963. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Mutual modulation be（680KB） | 限制开放 | ODC PDDL | 浏览 | |||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论