| Low Molecular Weight Fucoidan Alleviates Cardiac Dysfunction in Diabetic Goto-Kakizaki Rats by Reducing Oxidative Stress and Cardiomyocyte Apoptosis | |
| Yu, Xinfeng1; Zhang, Quanbin2; Cui, Wentong1; Zeng, Zheng1; Yang, Wenzhe1; Zhang, Chao1; Zhao, Hongwei1; Gao, Weidong3; Wang, Xiaomin4; Luo, Dali1; Luo, DL (reprint author), Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Dept Pharmacol, Youanmenwai St,10 Xitoutiao, Beijing 100069, Peoples R China. | |
| 2014 | |
| 发表期刊 | JOURNAL OF DIABETES RESEARCH
 |
| 页码 | 420929 |
| 文章类型 | Article |
| 摘要 | Diabetic cardiomyopathy (DCM) is characterized by cardiac dysfunction and cardiomyocyte apoptosis. Oxidative stress is suggested to be the major contributor to the development of DCM. This study was intended to evaluate the protective effect of low molecular weight fucoidan (LMWF) against cardiac dysfunction in diabetic rats. Type 2 diabetic goto-kakizaki rats were untreated or treated with LMWF (50 and 100 mg/kg/day) for three months. The establishment of DCM model and the effects of LMWF on cardiac function were evaluated by echocardiography and isolated heart perfusion. Ventricle staining with H-E or Sirius Red was performed to investigate the structural changes in myocardium. Functional evaluation demonstrated that LMWF has a beneficial effect on DCM by enhancing myocardial contractility and mitigating cardiac fibrosis. Additionally, LMWF exerted significant inhibitory effects on the reactive oxygen species production and myocyte apoptosis in diabetic hearts. The depressed activity of superoxide dismutase in diabetic heart was also improved by intervention with LMWF. Moreover, LMWF robustly inhibited the enhanced expression of protein kinase C beta, an important contributor to oxidative stress, in diabetic heart and high glucose-treated cardiomyocytes. In conclusion, LMWF possesses a protective effect against DCM through ameliorations of PKC beta-mediated oxidative stress and subsequent cardiomyocyte apoptosis in diabetes. |
| 学科领域 | Endocrinology & Metabolism ; Research & Experimental Medicine |
| DOI | 10.1155/2014/420929 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000346293300001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/24231 |
| 专题 | 海洋生物技术研发中心 |
| 通讯作者 | Luo, DL (reprint author), Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Dept Pharmacol, Youanmenwai St,10 Xitoutiao, Beijing 100069, Peoples R China. |
| 作者单位 | 1.Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Dept Pharmacol, Beijing 100069, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 3.Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21287 USA 4.Capital Med Univ, Dept Physiol, Beijing 100069, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Xinfeng,Zhang, Quanbin,Cui, Wentong,et al. Low Molecular Weight Fucoidan Alleviates Cardiac Dysfunction in Diabetic Goto-Kakizaki Rats by Reducing Oxidative Stress and Cardiomyocyte Apoptosis[J]. JOURNAL OF DIABETES RESEARCH,2014:420929. |
| APA | Yu, Xinfeng.,Zhang, Quanbin.,Cui, Wentong.,Zeng, Zheng.,Yang, Wenzhe.,...&Luo, DL .(2014).Low Molecular Weight Fucoidan Alleviates Cardiac Dysfunction in Diabetic Goto-Kakizaki Rats by Reducing Oxidative Stress and Cardiomyocyte Apoptosis.JOURNAL OF DIABETES RESEARCH,420929. |
| MLA | Yu, Xinfeng,et al."Low Molecular Weight Fucoidan Alleviates Cardiac Dysfunction in Diabetic Goto-Kakizaki Rats by Reducing Oxidative Stress and Cardiomyocyte Apoptosis".JOURNAL OF DIABETES RESEARCH (2014):420929. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Low Molecular Weight（5068KB） | 限制开放 | ODC PDDL | 浏览 | |||
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