| The Protective Effect of Fucoidan in Rats with Streptozotocin-Induced Diabetic Nephropathy | |
Wang, Jing1,3,4 ; Liu, Huaide2; Li, Ning1; Zhang, Quanbin1,3,4; Zhang, Hong1; Li, N (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
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| 2014-06-01 | |
| 发表期刊 | MARINE DRUGS
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| 卷号 | 12期号:6页码:3292-3306 |
| 文章类型 | Article |
| 摘要 | Diabetic nephropathy (DN) has long been recognized as the leading cause of end-stage renal disease, but the efficacy of available strategies for the prevention of DN remains poor. The aim of this study was to investigate the possible beneficial effects of fucoidan (FPS) in streptozotocin (STZ)-induced diabetes in rats. Wistar rats were made diabetic by injection of STZ after removal of the right kidney. FPS was administered to these diabetic rats for 10 weeks. Body weight, physical activity, renal function, and renal morphometry were measured after 10 weeks of treatment. In the FPS-treated group, the levels of blood glucose, BUN, Ccr and Ucr decreased significantly, and microalbumin, serum insulin and the beta 2-MG content increased significantly. Moreover, the FPS-treated group showed improvements in renal morphometry. In summary, FPS can ameliorate the metabolic abnormalities of diabetic rats and delay the progression of diabetic renal complications. |
| 关键词 | Sulfated Polysaccharide Fucoidan Diabetic Nephropathy |
| 学科领域 | Pharmacology & Pharmacy |
| DOI | 10.3390/md12063292 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000338189200011 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/24247 |
| 专题 | 海洋生物技术研发中心 |
| 通讯作者 | Li, N (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China. |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Nantong Univ, Sch Life Sci, Nantong 226019, Peoples R China 3.Chinese Acad Sci, Nantong Branch, Inst Oceanol, Nantong 226006, Jiangsu, Peoples R China 4.Collaborat Innovat Ctr Marine Biomass Fibers Mat, Qingdao 266071, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Jing,Liu, Huaide,Li, Ning,et al. The Protective Effect of Fucoidan in Rats with Streptozotocin-Induced Diabetic Nephropathy[J]. MARINE DRUGS,2014,12(6):3292-3306. |
| APA | Wang, Jing,Liu, Huaide,Li, Ning,Zhang, Quanbin,Zhang, Hong,&Li, N .(2014).The Protective Effect of Fucoidan in Rats with Streptozotocin-Induced Diabetic Nephropathy.MARINE DRUGS,12(6),3292-3306. |
| MLA | Wang, Jing,et al."The Protective Effect of Fucoidan in Rats with Streptozotocin-Induced Diabetic Nephropathy".MARINE DRUGS 12.6(2014):3292-3306. |
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