| Xanthohumol, a Prenylated Chalcone from Beer Hops, Acts as an alpha-Glucosidase Inhibitor in Vitro | |
| Liu, Ming1; Yin, Hua2; Liu, Ge3; Dong, Jianjun2; Qian, Zhonghua2; Miao, Jinlai2,4; Miao, JL (reprint author), State Key Lab Biol Fermentat Engn Beer, Qingdao 266061, Peoples R China. | |
| 2014-06-18 | |
| 发表期刊 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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| 卷号 | 62期号:24页码:5548-5554 |
| 文章类型 | Article |
| 摘要 | Xanthohumol (XN) is a unique prenylated flavonoid in hops (Humulus lupulus L.) and beer. XN alleviates hyperglycemia and has potential usage in the treatment of type 2 diabetes. In the present study, a series of in vitro experiments were performed to investigate whether XN was an effective inhibitor of alpha-glucosidase. The results showed that XN inhibited alpha-glucosidase in a reversible and noncompetitive manner, with an IC50 value of 8.8 mu M and that XN inhibited the release of glucose from the maltose in the apical side of the Caco-2 cell monolayer. Fluorescence and circular dichroism spectra results indicated that XN directly bound to alpha-glucosidase and induced minor conformational changes of the enzyme. These results demonstrated that XN is a promising alpha-glucosidase inhibitor, which therefore could be used as functional food to alleviate postprandial hyperglycemia and as a potential candidate for the development of an antidiabetic agent. |
| 关键词 | HumuL.s LupuL.s L. Xanthohumol Alpha-glucosidase Inhibitor |
| 学科领域 | Agriculture ; Chemistry ; Food Science & Technology |
| DOI | 10.1021/jf500426z |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000337720100018 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/24252 |
| 专题 | 海洋生物技术研发中心 |
| 通讯作者 | Miao, JL (reprint author), State Key Lab Biol Fermentat Engn Beer, Qingdao 266061, Peoples R China. |
| 作者单位 | 1.Ocean Univ China, Key Lab Marine Drugs, Minist Educ, Sch Med & Pharm, Qingdao 266003, Peoples R China 2.State Key Lab Biol Fermentat Engn Beer, Qingdao 266061, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 4.State Ocean Adm, Key Lab Marine Bioact Subst, Inst Oceanog 1, Qingdao 266061, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Ming,Yin, Hua,Liu, Ge,et al. Xanthohumol, a Prenylated Chalcone from Beer Hops, Acts as an alpha-Glucosidase Inhibitor in Vitro[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2014,62(24):5548-5554. |
| APA | Liu, Ming.,Yin, Hua.,Liu, Ge.,Dong, Jianjun.,Qian, Zhonghua.,...&Miao, JL .(2014).Xanthohumol, a Prenylated Chalcone from Beer Hops, Acts as an alpha-Glucosidase Inhibitor in Vitro.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,62(24),5548-5554. |
| MLA | Liu, Ming,et al."Xanthohumol, a Prenylated Chalcone from Beer Hops, Acts as an alpha-Glucosidase Inhibitor in Vitro".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 62.24(2014):5548-5554. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Xanthohumol, a Preny（772KB） | 限制开放 | ODC PDDL | 浏览 | |||
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