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Benzodiazepine Alkaloids from Marine-Derived Endophytic Fungus Aspergillus ochraceus
Cui, Chuan-Ming1,2; Li, Xiao-Ming1; Li, Chun-Shun1; Sun, Hao-Fen1; Gan, Shu-Shan1,2; Wang, Bin-Gui1
2009
发表期刊HELVETICA CHIMICA ACTA
ISSN0018-019X
卷号92期号:7页码:1366-1370
文章类型Article
摘要A new fungus-derived benzodiazepine analogue, 2-hydroxycircumdatin C (1), and a compound which has been isolated from a natural resource for the first time, but has been previously synthesized, namely (11aS)-2,3-dihydro-7-methoxy-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione (2), along with five structurally related known alkaloids (3-7), were isolated from Aspergillus ochraceus, an endophytic fungus derived from the marine brown alga Sargassum kjellmanianum. Their structures were established on the basis of spectroscopic methods. The absolute configuration of I was determined through CD evidence. Compound 1 displayed significant DPPH radical-scavenging activity with an IC(50) value of 9.9 mu M, which is 8.9-fold more potent than that of butylated hydroxytoluene (BHT), a well-known synthetic positive control.; A new fungus-derived benzodiazepine analogue, 2-hydroxycircumdatin C (1), and a compound which has been isolated from a natural resource for the first time, but has been previously synthesized, namely (11aS)-2,3-dihydro-7-methoxy-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione (2), along with five structurally related known alkaloids (3-7), were isolated from Aspergillus ochraceus, an endophytic fungus derived from the marine brown alga Sargassum kjellmanianum. Their structures were established on the basis of spectroscopic methods. The absolute configuration of I was determined through CD evidence. Compound 1 displayed significant DPPH radical-scavenging activity with an IC50 value of 9.9 mu M, which is 8.9-fold more potent than that of butylated hydroxytoluene (BHT), a well-known synthetic positive control.
关键词Niger En-13 Polysiphonia-urceolata Red Alga Circumdatin
学科领域Chemistry, Multidisciplinary
收录类别SCI ; IC
语种英语
WOS记录号WOS:000268622500016
引用统计
被引频次:58[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/2890
专题实验海洋生物学重点实验室
作者单位1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
第一作者单位实验海洋生物学重点实验室
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GB/T 7714
Cui, Chuan-Ming,Li, Xiao-Ming,Li, Chun-Shun,et al. Benzodiazepine Alkaloids from Marine-Derived Endophytic Fungus Aspergillus ochraceus[J]. HELVETICA CHIMICA ACTA,2009,92(7):1366-1370.
APA Cui, Chuan-Ming,Li, Xiao-Ming,Li, Chun-Shun,Sun, Hao-Fen,Gan, Shu-Shan,&Wang, Bin-Gui.(2009).Benzodiazepine Alkaloids from Marine-Derived Endophytic Fungus Aspergillus ochraceus.HELVETICA CHIMICA ACTA,92(7),1366-1370.
MLA Cui, Chuan-Ming,et al."Benzodiazepine Alkaloids from Marine-Derived Endophytic Fungus Aspergillus ochraceus".HELVETICA CHIMICA ACTA 92.7(2009):1366-1370.
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