| Chemical constituents of the red alga Laurencia tristicha | |
| Sun, Jie4; Shi, Da-Yong3,4; Li, Shuai1,2; Wang, Su-Juan1,2; Han, Li-Jun3; Fan, Xiao3; Yang, Yong-Chun1,2; Shi, Jian-Gong1,2 | |
| 2007 | |
| 发表期刊 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
 |
| 卷号 | 9期号:8页码:725-734 |
| 文章类型 | Article |
| 摘要 | Six new sesquiterpenes, 10-hydroxy-epiaplysin (1), 10-hydroxy-aplysin (2), 10-hydroxy-debromoepiaplysin (3), aplysin-9-ene (4), epiaplysinol (5) and debromoepiaplysinol (6), together with 13 known compounds (7-19), have been isolated from the red alga Laurencia tristicha. The structures of 1-6 were determined by spectroscopic methods including IR, EI-MS, HREI-MS, and 1D and 2D NMR techniques. All compounds were obtained from this species for the first time and were tested for cytotoxic activities against several human cancer cell lines including lung adenocarcinoma (A549), stomach cancer (BGC-823), hepatoma (Bel 7402), colon cancer (HCT-8) and HeLa cell lines. Compound 6 showed selective cytotoxicity against HeLa cell line with IC50 15.5 mu M, cholest-5-en-3 beta,7 alpha-diol (14) was toxic to all tested cell lines with IC50 values of 16.8, 5.1, 0.5, 0.5, and 0.3 mu M, respectively, and other compounds were inactive (IC50 > 10 mu g/ml). |
| 关键词 | Red Alga Laurencia Tristicha Chemical Constituents |
| DOI | 10.1080/10286020601103338 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000253300500006 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/32597 |
| 专题 | 海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 2.Pekeng Union Med Coll, Key Lab Bioact Substances & Resources Unilizat Ch, Minist Educ, Beijing 100050, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 4.Ludong Univ, Coll Life Sci, Yantai 264025, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Jie,Shi, Da-Yong,Li, Shuai,et al. Chemical constituents of the red alga Laurencia tristicha[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2007,9(8):725-734. |
| APA | Sun, Jie.,Shi, Da-Yong.,Li, Shuai.,Wang, Su-Juan.,Han, Li-Jun.,...&Shi, Jian-Gong.(2007).Chemical constituents of the red alga Laurencia tristicha.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,9(8),725-734. |
| MLA | Sun, Jie,et al."Chemical constituents of the red alga Laurencia tristicha".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 9.8(2007):725-734. |
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| Chemical constituent（178KB） | 期刊论文 | 出版稿 | 限制开放 | ODC PDDL | 浏览 | |
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