A new structure-based classification of sulfide:quinone oxidoreductases

doi:10.1002/prot.22665

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	A new structure-based classification of sulfide:quinone oxidoreductases
	Marcia, Marco 2; Ermler, Ulrich 2; Peng, Guohong 1,2; Michel, Hartmut 2
	2010-04-01
发表期刊	PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
卷号	78 期号:5 页码:1073-1083
文章类型	Review
摘要	Sulfide:quinone oxidoreductases (SQR) are ubiquitous membrane-bound flavoproteins involved in sulfide detoxification, in sulfide-dependent energy conservation processes and potenatially in the homeostasis of the neurotransmitter sulfide. The first 2 structures of SQRs from the bacterium Aquifex aeolicus (Marcia et al., Proc Nad Acad Sci USA 2009; 106:96259630) and the archaeon Acidianus ambivalens (Brito et al., Biochemistry 2009; 48:5613-5622) were determined recently by Xray crystallography revealing unexpected differences in the active sites and in flavin adenine dinucleotide binding. Besides the reciprocal differences, they show a different conformation of the active site compared with another sulfide oxidizing enzyme, the flavocytochrome c-sulfide dehydrogenase (FCSD) from Allochromatium vinosum (protein data bank id: 1FCD). In addition to the new structural data, the number of available SQR-like protein sequences is continuously increasing (Pham et aL, Microbiology 2008; 154:3112-3121) and the SQR activity of new members of this protein family was recently proven too (Chan et al., J Bacteriol 2009; 191:1026-1034). In the light of the new data, here we revisit the previously proposed contradictory SQR classification and we define new structure-based sequence fingerprints that support a subdivision of the SQR family into six groups. Our report summarizes the state-of-art knowledge about SQRs and highlights the questions that still remain unanswered. Despite two decades of work already done on these enzymes, new and most exciting discoveries can be expected in the future.
关键词	Flavoproteins Disulfide Reductase Superfamily Structure-functional Relationships Aquifex Aeolicus Acidianus Ambivalens Monotopic Membrane Proteins Flavin Adenine Dinucleotide Sulfur Polymerization Structure-based Sequence Alignment
DOI	10.1002/prot.22665
收录类别	SCI
语种	英语
WOS记录号	WOS:000275639500001
引用统计	被引频次：107[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.qdio.ac.cn/handle/337002/32767
专题	实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China 2.Max Planck Inst Biophys, Dept Mol Membrane Biol, D-60596 Frankfurt, Germany
推荐引用方式 GB/T 7714	Marcia, Marco,Ermler, Ulrich,Peng, Guohong,et al. A new structure-based classification of sulfide:quinone oxidoreductases[J]. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS,2010,78(5):1073-1083.
APA	Marcia, Marco,Ermler, Ulrich,Peng, Guohong,&Michel, Hartmut.(2010).A new structure-based classification of sulfide:quinone oxidoreductases.PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS,78(5),1073-1083.
MLA	Marcia, Marco,et al."A new structure-based classification of sulfide:quinone oxidoreductases".PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 78.5(2010):1073-1083.

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文件名称/大小	文献类型	版本类型	开放类型	使用许可
A new structure-base（1319KB）	期刊论文	出版稿	限制开放	ODC PDDL	浏览