Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
| Structure, absolute configuration, and conformational study of resorcylic acid derivatives and related congeners from the fungus Penicillium brocae | |
Zhang, Peng1,2 ; Meng, Ling-Hong1,2; Mandi, Attila3; Li, Xiao-Ming1; Kurtan, Tibor3; Wang, Bin-Gui1
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| 2015 | |
| 发表期刊 | RSC ADVANCES
 |
| 卷号 | 5期号:50页码:39870-39877 |
| 文章类型 | Article |
| 摘要 | In addition to three known resorcylic acid derivatives of the (14R) series (1-3), six new compounds including one new resorcylic acid derivative (13-hydroxydihydroresorcylide, 4) and five new loop-opened resorcylic acid-related congeners including brocapyrone A (5) and brocaketones A-D (6-9), were isolated and identified from the culture extract of a marine mangrove-derived endophytic fungus Penicillium brocae MA-192. Conformational analysis and TDDFT-ECD calculations of 1, 3, and 4 were carried out to confirm the (14R) absolute configuration and identify the solution conformers and factors that govern the correlation between stereochemistry and signs of the characteristic ECD bands. The single crystal X-ray of 3 and 5 allowed applying the solid-state TDDFT-ECD approach for 3 to compare the structures of solution and solid-state conformers and correlate the n-pi* ECD transition of 5 with the helicity and absolute configuration of the dihydroisocoumarin moiety. All compounds were evaluated for antioxidant activity against DPPH and ABTS radicals. |
| DOI | 10.1039/c5ra02203g |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000354211100028 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/33034 |
| 专题 | 实验海洋生物学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Debrecen, Dept Organ Chem, H-4010 Debrecen, Hungary |
| 第一作者单位 | 实验海洋生物学重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhang, Peng,Meng, Ling-Hong,Mandi, Attila,et al. Structure, absolute configuration, and conformational study of resorcylic acid derivatives and related congeners from the fungus Penicillium brocae[J]. RSC ADVANCES,2015,5(50):39870-39877. |
| APA | Zhang, Peng,Meng, Ling-Hong,Mandi, Attila,Li, Xiao-Ming,Kurtan, Tibor,&Wang, Bin-Gui.(2015).Structure, absolute configuration, and conformational study of resorcylic acid derivatives and related congeners from the fungus Penicillium brocae.RSC ADVANCES,5(50),39870-39877. |
| MLA | Zhang, Peng,et al."Structure, absolute configuration, and conformational study of resorcylic acid derivatives and related congeners from the fungus Penicillium brocae".RSC ADVANCES 5.50(2015):39870-39877. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Structure, absolute （535KB） | 期刊论文 | 出版稿 | 限制开放 | ODC PDDL | 浏览 | |
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