| Natural and semisynthetic protein tyrosine phosphatase 1B (PTP1B) inhibitors as anti-diabetic agents | |
| Wang, Li-Jun; Jiang, Bo; Wu, Ning; Wang, Shuai-Yu; Shi, Da-Yong | |
| 2015 | |
| 发表期刊 | RSC ADVANCES
 |
| 卷号 | 5期号:60页码:48822-48834 |
| 文章类型 | Review |
| 摘要 | Diabetes mellitus, which includes both type 1 and type 2 diabetes mellitus (T2DM), is a major disease that threatens human health worldwide. Protein tyrosine phosphatase 1B (PTP1B) is a promising molecular-level therapeutic target that is effective in the management of T2DM. Natural products with various skeletons and diverse bioactivities offer opportunities for the development of new drugs and lead compounds with potent inhibitory activity against PTP1B in vitro and in vivo. Recently, a number of potent PTP1B inhibitors have been obtained from natural sources or prepared by synthesis/semisynthesis, and they exhibit potential for the treatment of T2DM. In this review, we discuss the development of potent natural and semisynthetic PTP1B inhibitors with IC50 values under 10 mu M over the past six years (2009-2014), including their structural features, biological features, structure-activity relationships (SARs). We also discuss strategies for identifying potent PTP1B inhibitors from natural products to provide useful information for use by medicinal chemists in developing potent PTP1B inhibitors as T2DM treatments. |
| DOI | 10.1039/c5ra01754h |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000355738300078 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/33057 |
| 专题 | 海洋生物技术研发中心 |
| 作者单位 | Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 第一作者单位 | 中国科学院海洋研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Li-Jun,Jiang, Bo,Wu, Ning,et al. Natural and semisynthetic protein tyrosine phosphatase 1B (PTP1B) inhibitors as anti-diabetic agents[J]. RSC ADVANCES,2015,5(60):48822-48834. |
| APA | Wang, Li-Jun,Jiang, Bo,Wu, Ning,Wang, Shuai-Yu,&Shi, Da-Yong.(2015).Natural and semisynthetic protein tyrosine phosphatase 1B (PTP1B) inhibitors as anti-diabetic agents.RSC ADVANCES,5(60),48822-48834. |
| MLA | Wang, Li-Jun,et al."Natural and semisynthetic protein tyrosine phosphatase 1B (PTP1B) inhibitors as anti-diabetic agents".RSC ADVANCES 5.60(2015):48822-48834. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Natural and semisynt（1045KB） | 期刊论文 | 出版稿 | 限制开放 | ODC PDDL | 浏览 | |
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