| Fucoidan protects against dopaminergic neuron death in vivo and in vitro | |
| Luo, Dingzhen1; Zhang, Quanbin2; Wang, Haomin3; Cui, Yanqiu1; Sun, Zuoli1; Yang, Jian1; Zheng, Yan1; Jia, Jun1; Yu, Fen1; Wang, Xuan1; Wang, Xiaomin1 | |
| 2009-09-01 | |
| 发表期刊 | EUROPEAN JOURNAL OF PHARMACOLOGY
 |
| ISSN | 0014-2999 |
| 卷号 | 617期号:1-3页码:33-40 |
| 文章类型 | Article |
| 摘要 | Parkinson's disease is a neurodegenerative disorder of uncertain pathogenesis characterized by a loss of dopaminergic neurons in substantia nigra pars compacta, and can be modeled by the neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). Oxidative stress may contribute to MPTP- and Parkinson's disease-related neurodegeneration. Fucoidan is a sulfated polysaccharide extracted from brown seaweeds which possesses a wide variety of biological activities including potent antioxidative effects. Here we investigated the effect of fucoidan treatment on locomoter activities of animals, striatal dopamine and its metabolites and survival of nigral dopaminergic neurons in MPTP-induced animal model of Parkinsonism in C57/BL mice in vivo and on the neuronal damage induced by 1-methyl-4-phenylpyridinium (MPP(+)) in vitro, and to study the possible mechanisms. When administered prior to MPTP, fucoidan reduced behavioral deficits, increased striatal dopamine and its metabolites levels, reduced cell death, and led to a marked increase in tyrosine hydroxylase expression relative to mice treated with MPTP alone. Furthermore, we found that fucoidan inhibited MPTP-induced lipid peroxidation and reduction of antioxidant enzyme activity. In addition, pre-treatment with fucoidan significantly protected against MPP(+)-induced damage in MN9D cells. Taken together, these findings suggest that fucoidan has protective effect in MPTP-induced neurotoxicity in this model of Parkinson's disease via its antioxidative activity. (C) 2009 Elsevier B.V. All rights reserved.; Parkinson's disease is a neurodegenerative disorder of uncertain pathogenesis characterized by a loss of dopaminergic neurons in substantia nigra pars compacta, and can be modeled by the neurotoxin 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). Oxidative stress may contribute to MPTP- and Parkinson's disease-related neurodegeneration. Fucoidan is a sulfated polysaccharide extracted from brown seaweeds which possesses a wide variety of biological activities including potent antioxidative effects. Here we investigated the effect of fucoidan treatment on locomoter activities of animals, striatal dopamine and its metabolites and survival of nigral dopaminergic neurons in MPTP-induced animal model of Parkinsonism in C57/BL mice in vivo and on the neuronal damage induced by 1-methyl-4-phenylpyridinium (MPP+) in vitro, and to study the possible mechanisms. When administered prior to MPTP, fucoidan reduced behavioral deficits, increased striatal dopamine and its metabolites levels, reduced cell death, and led to a marked increase in tyrosine hydroxylase expression relative to mice treated with MPTP alone. Furthermore, we found that fucoidan inhibited MPTP-induced lipid peroxidation and reduction of antioxidant enzyme activity. In addition, pre-treatment with fucoidan significantly protected against MPP+-induced damage in MN9D cells. Taken together, these findings suggest that fucoidan has protective effect in MPTP-induced neurotoxicity in this model of Parkinson's disease via its antioxidative activity. (C) 2009 Elsevier B.V. All rights reserved. |
| 关键词 | Fucoidan Neuroprotection Antioxidant Activity Oxidative Stress Parkinson's Disease 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine |
| 学科领域 | Pharmacology & Pharmacy |
| DOI | 10.1016/j.ejphar.2009.06.015 |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000269867400006 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.qdio.ac.cn/handle/337002/3476 |
| 专题 | 海洋生物技术研发中心 |
| 作者单位 | 1.Capital Med Univ, Minist Educ, Key Lab Neurodegenerat Dis, Beijing 100069, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 3.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, Dingzhen,Zhang, Quanbin,Wang, Haomin,et al. Fucoidan protects against dopaminergic neuron death in vivo and in vitro[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2009,617(1-3):33-40. |
| APA | Luo, Dingzhen.,Zhang, Quanbin.,Wang, Haomin.,Cui, Yanqiu.,Sun, Zuoli.,...&Wang, Xiaomin.(2009).Fucoidan protects against dopaminergic neuron death in vivo and in vitro.EUROPEAN JOURNAL OF PHARMACOLOGY,617(1-3),33-40. |
| MLA | Luo, Dingzhen,et al."Fucoidan protects against dopaminergic neuron death in vivo and in vitro".EUROPEAN JOURNAL OF PHARMACOLOGY 617.1-3(2009):33-40. |
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