IOCAS-IR  > 实验海洋生物学重点实验室
Nigerapyrones A-H, alpha-Pyrone Derivatives from the Marine Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132
Liu, Dong2,3; Li, Xiao-Ming2; Meng, Li1; Li, Chun-Shun2; Gao, Shu-Shan2,3; Shang, Zhuo2,3; Proksch, Peter4; Huang, Cai-Guo1; Wang, Bin-Gui2
2011-08-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号74期号:8页码:1787-1791
文章类型Article
摘要Eight new a-pyrone derivatives, namely, nigerapyrones A-E (1-5) and nigerapyrones F-H (8-10), along with two known congeners, asnipyrones B (6) and A (7), were isolated from Aspergillus niger MA-132, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these compounds were elucidated on the basis of spectroscopic analysis. The undescribed geometries of the trisubstituted double bonds (C-9 and C-11) for asnipyrone B (6) have now been explicitly determined, while the incorrect placement of the methyl group at C-5 of asnipyrone A (7) has now been revised at C-3. The cytotoxic activities of the isolated a-pyrone derivatives against eight tumor cell lines as well as antimicrobial activities against two bacteria and four plant-pathogenic fungi of these compounds were evaluated. Compounds 2, 4, 5, and 7 showed weak cytotoxicity against some of the tested tumor cell lines.; Eight new a-pyrone derivatives, namely, nigerapyrones A-E (1-5) and nigerapyrones F-H (8-10), along with two known congeners, asnipyrones B (6) and A (7), were isolated from Aspergillus niger MA-132, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these compounds were elucidated on the basis of spectroscopic analysis. The undescribed geometries of the trisubstituted double bonds (C-9 and C-11) for asnipyrone B (6) have now been explicitly determined, while the incorrect placement of the methyl group at C-5 of asnipyrone A (7) has now been revised at C-3. The cytotoxic activities of the isolated a-pyrone derivatives against eight tumor cell lines as well as antimicrobial activities against two bacteria and four plant-pathogenic fungi of these compounds were evaluated. Compounds 2, 4, 5, and 7 showed weak cytotoxicity against some of the tested tumor cell lines.
学科领域Plant Sciences ; Pharmacology & Pharmacy
DOI10.1021/np200381u
URL查看原文
收录类别SCI ; IC
语种英语
WOS记录号WOS:000294242800016
引用统计
被引频次:102[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.qdio.ac.cn/handle/337002/11907
专题实验海洋生物学重点实验室
作者单位1.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China
2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
4.Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, D-40225 Dusseldorf, Germany
第一作者单位实验海洋生物学重点实验室
推荐引用方式
GB/T 7714
Liu, Dong,Li, Xiao-Ming,Meng, Li,et al. Nigerapyrones A-H, alpha-Pyrone Derivatives from the Marine Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(8):1787-1791.
APA Liu, Dong.,Li, Xiao-Ming.,Meng, Li.,Li, Chun-Shun.,Gao, Shu-Shan.,...&Wang, Bin-Gui.(2011).Nigerapyrones A-H, alpha-Pyrone Derivatives from the Marine Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132.JOURNAL OF NATURAL PRODUCTS,74(8),1787-1791.
MLA Liu, Dong,et al."Nigerapyrones A-H, alpha-Pyrone Derivatives from the Marine Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132".JOURNAL OF NATURAL PRODUCTS 74.8(2011):1787-1791.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Nigerapyrones A-H al(752KB) 限制开放--浏览
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, Dong]的文章
[Li, Xiao-Ming]的文章
[Meng, Li]的文章
百度学术
百度学术中相似的文章
[Liu, Dong]的文章
[Li, Xiao-Ming]的文章
[Meng, Li]的文章
必应学术
必应学术中相似的文章
[Liu, Dong]的文章
[Li, Xiao-Ming]的文章
[Meng, Li]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Nigerapyrones A-H alpha-Pyrone Derivatives from the Marine Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。