Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Varioloid A, a new indolyl-6,10b-dihydro-5aH-[1]benzofuro[2,3-b]indole derivative from the marine alga-derived endophytic fungus Paecilomyces variotii EN-291 | |
Zhang, Peng1,2; Li, Xiao-Ming1; Mao, Xin-Xin2; Mandi, Attila3; Kurtan, Tibor3; Wang, Bin-Gui1 | |
2016-09-09 | |
发表期刊 | BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY |
ISSN | 1860-5397 |
卷号 | 12页码:2012-2018 |
通讯作者 | Kurtan, Tibor(kurtan.tibor@science.unideb.hu) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
摘要 | A new indolyl-6,10b-dihydro-5aH-[1]benzofuro[2,3-b]indole derivative, varioloid A (1), was isolated from the marine alga-derived endophytic fungus Paecilomyces variotii EN-291. Its structure was elucidated on the basis of extensive analysis of 1D and 2D NMR data and the absolute configuration was determined by time-dependent density functional theory-electronic circular dichroism (TDDFT-ECD) calculations. A similar compound, whose planar structure was previously described but the relative and absolute configurations and C-13 NMR data were not reported, was also identified and was tentatively named as varioloid B (2). Both compounds 1 and 2 exhibited cytotoxicity against A549, HCT116, and HepG2 cell lines, with IC50 values ranging from 2.6 to 8.2 mu g/mL. |
关键词 | bisindolyl benzenoid derivatives cytotoxicity marine alga-derived fungus Paecilomyces variotii TDDFT-ECD calculation |
DOI | 10.3762/bjoc.12.188 |
收录类别 | SCI |
语种 | 英语 |
资助项目 | Natural Science Foundation of China[31330009] ; Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02] ; Hungarian National Research Foundation (OTKA)[K105871] ; Natural Science Foundation of China[31330009] ; Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology[2015ASKJ02] ; Hungarian National Research Foundation (OTKA)[K105871] |
WOS研究方向 | Chemistry |
WOS类目 | Chemistry, Organic |
WOS记录号 | WOS:000382737600001 |
出版者 | BEILSTEIN-INSTITUT |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qdio.ac.cn/handle/337002/157258 |
专题 | 实验海洋生物学重点实验室 |
通讯作者 | Kurtan, Tibor; Wang, Bin-Gui |
作者单位 | 1.Chinese Acad Sci, Lab Marine Biol & Biotechnol, Qingdao Natl Lab Marine Sci & Technol, Key Lab Expt Marine Biol,Inst Oceanol, Nanhai Rd 7, Qingdao 266071, Peoples R China 2.Chinese Acad Agr Sci, Tobacco Res Inst, Qingdao 266101, Peoples R China 3.Univ Debrecen, Dept Organ Chem, POB 400, H-4002 Debrecen, Hungary |
第一作者单位 | 中国科学院海洋研究所 |
通讯作者单位 | 中国科学院海洋研究所 |
推荐引用方式 GB/T 7714 | Zhang, Peng,Li, Xiao-Ming,Mao, Xin-Xin,et al. Varioloid A, a new indolyl-6,10b-dihydro-5aH-[1]benzofuro[2,3-b]indole derivative from the marine alga-derived endophytic fungus Paecilomyces variotii EN-291[J]. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,2016,12:2012-2018. |
APA | Zhang, Peng,Li, Xiao-Ming,Mao, Xin-Xin,Mandi, Attila,Kurtan, Tibor,&Wang, Bin-Gui.(2016).Varioloid A, a new indolyl-6,10b-dihydro-5aH-[1]benzofuro[2,3-b]indole derivative from the marine alga-derived endophytic fungus Paecilomyces variotii EN-291.BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY,12,2012-2018. |
MLA | Zhang, Peng,et al."Varioloid A, a new indolyl-6,10b-dihydro-5aH-[1]benzofuro[2,3-b]indole derivative from the marine alga-derived endophytic fungus Paecilomyces variotii EN-291".BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY 12(2016):2012-2018. |
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