Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Coral gasdermin triggers pyroptosis | |
Jiang, Shuai1,2,3,4; Zhou, Zhi5; Sun, Yuanyuan1,2,3; Zhang, Tengfei1,2,3,4; Sun, Li1,2,3,4 | |
2020-12-01 | |
发表期刊 | SCIENCE IMMUNOLOGY |
ISSN | 2470-9468 |
卷号 | 5期号:54页码:10 |
通讯作者 | Sun, Li(lsun@qdio.ac.cn) |
摘要 | Gasdermins are executioners of the inflammatory cell death pathway pyroptosis that has so far been studied exclusively in vertebrates. In this study, we identified gasdermin E (GSDME) homologs in several invertebrate species including corals. We report that coral GSDME was cleaved by caspase 3 at two sites, yielding two active isoforms of GSDME N-terminal domain that were capable of inducing pyroptosis. Ectopic coexpression of coral GSDME and caspase 3 in human cells promoted pyroptosis. Corals infected with Vibrio coralliilyticus, a bacterial pathogen causing rapid tissue necrosis of corals worldwide, exhibited necrotic death with elevated caspase 3 activity and GSDME cleavage, whereas inhibition of caspase 3 blocked GSDME cleavage and protected corals from necrotic death. These results indicate that functional gasdermin exists in invertebrates and that coral gasdermin is involved in pathogen-induced coral death. Furthermore, our studies also suggest that mediation of pyroptosis is an evolutionarily conserved function of gasdermins. |
DOI | 10.1126/sciimmunol.abd2591 |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[41876175] ; National Key Research and Development Project of China[2018YFD0900504] ; Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao)[2018SDKJ0302-2] ; Distinguished Young Scientists Research Fund of Key Laboratory of Experimental Marine Biology, Chinese Academy of Sciences[KLEMB-DYS03] ; Taishan Scholar Program of Shandong Province |
WOS研究方向 | Immunology |
WOS类目 | Immunology |
WOS记录号 | WOS:000596699100002 |
出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qdio.ac.cn/handle/337002/169375 |
专题 | 实验海洋生物学重点实验室 |
通讯作者 | Sun, Li |
作者单位 | 1.Chinese Acad Sci, CAS Key Lab Expt Marine Biol, Inst Oceanol, Qingdao, Peoples R China 2.Chinese Acad Sci, CAS Ctr Ocean Megasci, Qingdao, Peoples R China 3.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Hainan Univ, State Key Lab Marine Resource Utilizat South Chin, Haikou, Hainan, Peoples R China |
第一作者单位 | 中国科学院海洋研究所; 中国科学院海洋大科学研究中心 |
通讯作者单位 | 中国科学院海洋研究所; 中国科学院海洋大科学研究中心 |
推荐引用方式 GB/T 7714 | Jiang, Shuai,Zhou, Zhi,Sun, Yuanyuan,et al. Coral gasdermin triggers pyroptosis[J]. SCIENCE IMMUNOLOGY,2020,5(54):10. |
APA | Jiang, Shuai,Zhou, Zhi,Sun, Yuanyuan,Zhang, Tengfei,&Sun, Li.(2020).Coral gasdermin triggers pyroptosis.SCIENCE IMMUNOLOGY,5(54),10. |
MLA | Jiang, Shuai,et al."Coral gasdermin triggers pyroptosis".SCIENCE IMMUNOLOGY 5.54(2020):10. |
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sciimmunol.abd2591.p(1656KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 |
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