Institutional Repository of Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences
Tanzawaic Acid Derivatives: Fungal Polyketides from the Deep-Sea Coral-Derived Endozoic Penicillium steckii AS-324 | |
Hu, Xue-Yi1,2,3![]() ![]() ![]() | |
2022-05-27 | |
发表期刊 | JOURNAL OF NATURAL PRODUCTS
![]() |
ISSN | 0163-3864 |
卷号 | 85期号:5页码:1398-1406 |
通讯作者 | Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) ; Meng, Ling-Hong() |
摘要 | Ten new tanzawaic acids, namely, steckwaic acids A-D (1-4), 11-ketotanzawaic acid D (5), 6,15-dihydroxytanzawaic acid M (6), 15R-methoxytanzawaic acid M (7), 15S-methoxytanzawaic acid M (8), 8-hydroxytanzawaic acid M (9), and 8-hydroxytanzawaic acid B (10), together with four known analogues (11-14), were isolated and identified from the endozoic fungus Penicillium steckii AS-324, which was obtained from a deep-sea Acanthogorgiidae sp. coral that was collected from the Magellan seamount in the Western Pacific Ocean. Structurally, steckwaic acids A-D (1-4) represent the first tanzawaic acid derivatives containing a naphthalene ring. Their structures were elucidated by detailed interpretation of the NMR spectroscopic and mass spectrometric data. X-ray crystallographic analysis and ECD calculations confirmed their structures and absolute configurations. New compounds 1, 5, and 9 exhibited activities against aquatic pathogenic bacteria Micrococcus luteus, Vibrio anguillarum, and Pseudomonas aeruginosa with MICs of 2, 4, and 4 mu g/mL, respectively. |
DOI | 10.1021/acs.jnatprod.2c00211 |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[41976090] ; National Natural Science Foundation of China[42176115] ; Natural Science Foundation of Jiangsu Province[BK20201211] ; Natural Science Foundation of Jiangsu Province[KEXUE2020GZ02] ; National Major Science and Technology Infrastructure from the Chinese Academy of Sciences |
WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
WOS类目 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
WOS记录号 | WOS:000806554600022 |
出版者 | AMER CHEMICAL SOC |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qdio.ac.cn/handle/337002/179462 |
专题 | 实验海洋生物学重点实验室 |
通讯作者 | Wang, Bin-Gui; Meng, Ling-Hong |
作者单位 | 1.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Coll Marine Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China |
第一作者单位 | 中国科学院海洋研究所 |
通讯作者单位 | 中国科学院海洋研究所; 中国科学院海洋大科学研究中心 |
推荐引用方式 GB/T 7714 | Hu, Xue-Yi,Li, Xiao-Ming,Wang, Bin-Gui,et al. Tanzawaic Acid Derivatives: Fungal Polyketides from the Deep-Sea Coral-Derived Endozoic Penicillium steckii AS-324[J]. JOURNAL OF NATURAL PRODUCTS,2022,85(5):1398-1406. |
APA | Hu, Xue-Yi,Li, Xiao-Ming,Wang, Bin-Gui,&Meng, Ling-Hong.(2022).Tanzawaic Acid Derivatives: Fungal Polyketides from the Deep-Sea Coral-Derived Endozoic Penicillium steckii AS-324.JOURNAL OF NATURAL PRODUCTS,85(5),1398-1406. |
MLA | Hu, Xue-Yi,et al."Tanzawaic Acid Derivatives: Fungal Polyketides from the Deep-Sea Coral-Derived Endozoic Penicillium steckii AS-324".JOURNAL OF NATURAL PRODUCTS 85.5(2022):1398-1406. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
acs.jnatprod.2c00211(2270KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 浏览 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论