Institutional Repository of Key Laboratory of Marine Ecology & Environmental Sciences, CAS
Immunomodulation and antitumor activity of kappa-carrageenan oligosaccharides | |
Yuan, Huamao; Song, Jinming; Li, Xuegang; Li, Ning; Dai, Jicui | |
2006-11-18 | |
发表期刊 | CANCER LETTERS |
ISSN | 0304-3835 |
卷号 | 243期号:2页码:228-234 |
文章类型 | Article |
摘要 | The modulation of carrageenan oligosaccharides from Kappaphycus striatum on the immune system in S 180-bearing mice was investigated. The mice inoculated with S180 cell suspension were treated p.o. with carrageenan oligosaccharides (50, 100 and 200 mu g/g) for 14 days. The effects of carrageenan oligosaccharides on transplantable tumors and macrophage phagocytosis, quantitative hemolysis of sheep red blood cells (QHS),. lymphocyte proliferation, the activity of natural killer cells (NK), production of interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) were studied. Carrageenan oligosaccharides could significantly inhibit the growth of transplantable sarcoma S180 and increase macrophage phagocytosis, the form of antibody secreted by spleen cells, spleen lymphocyte proliferation, NK cells activity, serumal IL-2 and TNF-alpha level in S 180-bearing mice. Considering all these results, it is suggested that carrageenan oligosaccharides exert their antitumor effect by promoting the immune system. (c) 2005 Elsevier Ireland Ltd. All rights reserved.; The modulation of carrageenan oligosaccharides from Kappaphycus striatum on the immune system in S 180-bearing mice was investigated. The mice inoculated with S180 cell suspension were treated p.o. with carrageenan oligosaccharides (50, 100 and 200 mu g/g) for 14 days. The effects of carrageenan oligosaccharides on transplantable tumors and macrophage phagocytosis, quantitative hemolysis of sheep red blood cells (QHS),. lymphocyte proliferation, the activity of natural killer cells (NK), production of interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) were studied. Carrageenan oligosaccharides could significantly inhibit the growth of transplantable sarcoma S180 and increase macrophage phagocytosis, the form of antibody secreted by spleen cells, spleen lymphocyte proliferation, NK cells activity, serumal IL-2 and TNF-alpha level in S 180-bearing mice. Considering all these results, it is suggested that carrageenan oligosaccharides exert their antitumor effect by promoting the immune system. (c) 2005 Elsevier Ireland Ltd. All rights reserved. |
关键词 | Carrageenan Oligosaccharides Antitumor Immunomodulation |
学科领域 | Oncology |
DOI | 10.1016/j.canlet.2005.11.032 |
URL | 查看原文 |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000242481900008 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.qdio.ac.cn/handle/337002/5488 |
专题 | 海洋生态与环境科学重点实验室 |
作者单位 | 1.Acad Sinica, Inst Oceanol, Qingdao 266071, Peoples R China 2.Acad Sinica, Grad Sch, Beijing 100039, Peoples R China |
推荐引用方式 GB/T 7714 | Yuan, Huamao,Song, Jinming,Li, Xuegang,et al. Immunomodulation and antitumor activity of kappa-carrageenan oligosaccharides[J]. CANCER LETTERS,2006,243(2):228-234. |
APA | Yuan, Huamao,Song, Jinming,Li, Xuegang,Li, Ning,&Dai, Jicui.(2006).Immunomodulation and antitumor activity of kappa-carrageenan oligosaccharides.CANCER LETTERS,243(2),228-234. |
MLA | Yuan, Huamao,et al."Immunomodulation and antitumor activity of kappa-carrageenan oligosaccharides".CANCER LETTERS 243.2(2006):228-234. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
yuan-Immunomodulatio(112KB) | 限制开放 | -- | 浏览 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论